methyl (E)-7-(benzyloxy)-6-hydroxy-[(4-methoxyphenoxy)methyl]-2-heptanoate

Base Information

Chemical Name:methyl (E)-7-(benzyloxy)-6-hydroxy-[(4-methoxyphenoxy)methyl]-2-heptanoate
CAS No.:249930-24-3
Molecular Formula:C₂₃H₂₈O₆
Molecular Weight:400.472
Hs Code.:

Synonyms:methyl (E)-7-(benzyloxy)-6-hydroxy-[(4-methoxyphenoxy)methyl]-2-heptanoate

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Chemical Property of methyl (E)-7-(benzyloxy)-6-hydroxy-[(4-methoxyphenoxy)methyl]-2-heptanoate

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Technology Process of methyl (E)-7-(benzyloxy)-6-hydroxy-[(4-methoxyphenoxy)methyl]-2-heptanoate

There total 6 articles about methyl (E)-7-(benzyloxy)-6-hydroxy-[(4-methoxyphenoxy)methyl]-2-heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 5-benzyloxymethyl-5-(4-methoxy-phenoxymethyl)-4,5-dihydro-furan-2-ol

: 249930-24-3
methyl (E)-7-(benzyloxy)-6-hydroxy-[(4-methoxyphenoxy)methyl]-2-heptanoate

Guidance literature:: In toluene; for 2h; Heating;
DOI:10.1021/jm980713g

Reference yield:

: 2211-94-1,26744-15-0
2,3-epoxypropyl p-methoxyphenyl ether

: 249930-24-3
methyl (E)-7-(benzyloxy)-6-hydroxy-[(4-methoxyphenoxy)methyl]-2-heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 90 percent / dimethylformamide / 4 h / 80 °C

2.1: 92 percent / pyridinium chloroformate; 4A molecular sieve / CH₂Cl₂ / 24 h / 20 °C

3.1: Mg / tetrahydrofuran / 0 - 20 °C

3.2: 82 percent / tetrahydrofuran / 20 °C

4.1: 60 percent / 4-methylmorpholine N-oxide; OsO₄; NaIO₄ / acetone; 2-methyl-propan-2-ol; H₂O / 20 h / 20 °C

5.1: 87 percent / toluene / 2 h / Heating

With sodium periodate; osmium(VIII) oxide; pyridinium chloroformate; 4 A molecular sieve; sodium hydride; magnesium; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol; 1.1: Metallation / 1.2: Ring cleavage / 2.1: Oxidation / 3.1: Grignard reaction / 3.2: Addition / 4.1: dihydroxylation, diol cleavage / 5.1: Condensation;
DOI:10.1021/jm980713g

Reference yield:

: 213828-28-5
1-(benzyloxy)-3-(4-methoxyphenoxy)acetone

: 249930-24-3
methyl (E)-7-(benzyloxy)-6-hydroxy-[(4-methoxyphenoxy)methyl]-2-heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Mg / tetrahydrofuran / 0 - 20 °C

1.2: 82 percent / tetrahydrofuran / 20 °C

2.1: 60 percent / 4-methylmorpholine N-oxide; OsO₄; NaIO₄ / acetone; 2-methyl-propan-2-ol; H₂O / 20 h / 20 °C

3.1: 87 percent / toluene / 2 h / Heating

With sodium periodate; osmium(VIII) oxide; magnesium; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; acetone; toluene; tert-butyl alcohol; 1.1: Grignard reaction / 1.2: Addition / 2.1: dihydroxylation, diol cleavage / 3.1: Condensation;
DOI:10.1021/jm980713g