4-{2-ethyl-4-[1-(phenylsulfonyl)-1H-indol-6-yl]-1,3-thiazol-5-yl}-N-[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]-2-pyrimidinamine

Base Information

• Chemical Name: 4-{2-ethyl-4-[1-(phenylsulfonyl)-1H-indol-6-yl]-1,3-thiazol-5-yl}-N-[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]-2-pyrimidinamine
• CAS No.: 1126431-98-8
• Molecular Formula: C₃₇H₃₇FN₆O₅S₃
• Molecular Weight: 760.934

Synonyms:4-{2-ethyl-4-[1-(phenylsulfonyl)-1H-indol-6-yl]-1,3-thiazol-5-yl}-N-[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]-2-pyrimidinamine

Chemical Property of 4-{2-ethyl-4-[1-(phenylsulfonyl)-1H-indol-6-yl]-1,3-thiazol-5-yl}-N-[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]-2-pyrimidinamine

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Technology Process of 4-{2-ethyl-4-[1-(phenylsulfonyl)-1H-indol-6-yl]-1,3-thiazol-5-yl}-N-[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]-2-pyrimidinamine

There total 1 articles about 4-{2-ethyl-4-[1-(phenylsulfonyl)-1H-indol-6-yl]-1,3-thiazol-5-yl}-N-[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]amine (1126430-32-7) + 6-[5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl]-1-(phenylsulfonyl)-1H-indole (1126431-97-7) → 4-{2-ethyl-4-[1-(phenylsulfonyl)-1H-indol-6-yl]-1,3-thiazol-5-yl}-N-[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]-2-pyrimidinamine (1126431-98-8)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 170 ℃; for 0.583333h; Microwave irradiation;

Reference yield: 93.0%

4-{2-ethyl-4-[1-(phenylsulfonyl)-1H-indol-6-yl]-1,3-thiazol-5-yl}-N-[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]-2-pyrimidinamine (1126431-98-8) → 4-[2-ethyl-4-(1H-indol-6-yl)-1,3-thiazol-5-yl]-N-[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]-2-pyrimidinamine (1126431-93-3)

Guidance literature:

With sodium hydroxide; water; In methanol; at 50 ℃; for 2h;

upstream raw materials:

[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]amine

6-[5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl]-1-(phenylsulfonyl)-1H-indole

Downstream raw materials:

4-[2-ethyl-4-(1H-indol-6-yl)-1,3-thiazol-5-yl]-N-[3-fluoro-4-({1-[2-(methylsulfonyl)ethyl]-4-piperidinyl}oxy)phenyl]-2-pyrimidinamine

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