Technology Process of 3-(((1R,2R)-1,2-dihydroxy-5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl))methoxyphenyl benzoate
There total 8 articles about 3-(((1R,2R)-1,2-dihydroxy-5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl))methoxyphenyl benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; methanesulfonamide; AD-mix β;
In
dichloromethane; water; tert-butyl alcohol;
at 20 ℃;
for 72h;
Overall yield = 85 %; Overall yield = 370 mg; enantioselective reaction;
Inert atmosphere;
DOI:10.1039/c3cc42385a
- Guidance literature:
-
Multi-step reaction with 7 steps
1: aluminum (III) chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2: sodium hydride / paraffin oil / 90 °C / Inert atmosphere
3: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C / Inert atmosphere
4: pyridinium p-toluenesulfonate / toluene / Inert atmosphere; Reflux; Dean-Stark
5: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 °C / Inert atmosphere
6: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere
7: AD-mix β; methanesulfonamide; osmium(VIII) oxide / dichloromethane; tert-butyl alcohol; water / 72 h / 20 °C / Inert atmosphere
With
aluminum (III) chloride; sodium tetrahydroborate; osmium(VIII) oxide; methanesulfonamide; AD-mix β; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; paraffin oil; tert-butyl alcohol;
DOI:10.1039/c3cc42385a
- Guidance literature:
-
Multi-step reaction with 3 steps
1: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 °C / Inert atmosphere
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere
3: AD-mix β; methanesulfonamide; osmium(VIII) oxide / dichloromethane; tert-butyl alcohol; water / 72 h / 20 °C / Inert atmosphere
With
osmium(VIII) oxide; methanesulfonamide; AD-mix β; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1039/c3cc42385a
