Technology Process of Acetic acid 3-amino-2-((E)-1-benzyloxymethyl-5-hydroxy-pent-2-enyl)-4,6-dimethoxy-5-methyl-phenyl ester
There total 8 articles about Acetic acid 3-amino-2-((E)-1-benzyloxymethyl-5-hydroxy-pent-2-enyl)-4,6-dimethoxy-5-methyl-phenyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: LiAlH4, AlCl3 / diethyl ether / 1.) 0 deg C to RT, 30 min; 2.) 2 h
2: pyridinium chlorochromate, Celite / CH2Cl2 / 3 h
3: trimethyl borate, Zn / tetrahydrofuran / 6 h
4: LiAlH4 / diethyl ether / 0.25 h
5: 80 percent / 4-dimethylaminopyridine, triethylamine / CH2Cl2 / 16 h / Ambient temperature
7: 1.) Hg(OAc)2, 90 percent HNO3; 2.) conc. HCl, Zn / 1.) Ac2O, glacial AcOH, 0 deg C, 5 min; 2.) methanol, 25 deg C, 15 min
With
hydrogenchloride; dmap; lithium aluminium tetrahydride; aluminium trichloride; Trimethyl borate; Celite; mercury(II) diacetate; nitric acid; triethylamine; pyridinium chlorochromate; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00299a022
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trimethyl borate, Zn / tetrahydrofuran / 6 h
2: LiAlH4 / diethyl ether / 0.25 h
3: 80 percent / 4-dimethylaminopyridine, triethylamine / CH2Cl2 / 16 h / Ambient temperature
5: 1.) Hg(OAc)2, 90 percent HNO3; 2.) conc. HCl, Zn / 1.) Ac2O, glacial AcOH, 0 deg C, 5 min; 2.) methanol, 25 deg C, 15 min
With
hydrogenchloride; dmap; lithium aluminium tetrahydride; Trimethyl borate; mercury(II) diacetate; nitric acid; triethylamine; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00299a022
- Guidance literature:
-
Multi-step reaction with 6 steps
1: pyridinium chlorochromate, Celite / CH2Cl2 / 3 h
2: trimethyl borate, Zn / tetrahydrofuran / 6 h
3: LiAlH4 / diethyl ether / 0.25 h
4: 80 percent / 4-dimethylaminopyridine, triethylamine / CH2Cl2 / 16 h / Ambient temperature
6: 1.) Hg(OAc)2, 90 percent HNO3; 2.) conc. HCl, Zn / 1.) Ac2O, glacial AcOH, 0 deg C, 5 min; 2.) methanol, 25 deg C, 15 min
With
hydrogenchloride; dmap; lithium aluminium tetrahydride; Trimethyl borate; Celite; mercury(II) diacetate; nitric acid; triethylamine; pyridinium chlorochromate; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00299a022
