<1R-(1α,2β,3α)>-1-<2,3-bis<(benzoyloxy)methyl>cyclobutyl>-2,4(1H,3H)-pyrimidinedione

Base Information

• Chemical Name: <1R-(1α,2β,3α)>-1-<2,3-bis<(benzoyloxy)methyl>cyclobutyl>-2,4(1H,3H)-pyrimidinedione
• CAS No.: 140631-82-9
• Molecular Formula: C₂₄H₂₂N₂O₆
• Molecular Weight: 434.448
• Mol file: 140631-82-9.mol

Synonyms:<1R-(1α,2β,3α)>-1-<2,3-bis<(benzoyloxy)methyl>cyclobutyl>-2,4(1H,3H)-pyrimidinedione

Chemical Property of <1R-(1α,2β,3α)>-1-<2,3-bis<(benzoyloxy)methyl>cyclobutyl>-2,4(1H,3H)-pyrimidinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <1R-(1α,2β,3α)>-1-<2,3-bis<(benzoyloxy)methyl>cyclobutyl>-2,4(1H,3H)-pyrimidinedione

There total 2 articles about <1R-(1α,2β,3α)>-1-<2,3-bis<(benzoyloxy)methyl>cyclobutyl>-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

(1α,2β,3β)-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol, dibenzoate ester (126261-74-3,127759-91-5,132294-18-9,132294-26-9) + uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6) → (1α,2β,3α)-1-<2,3-bis-<(benzoyloxy)methyl>cyclobutyl>-2,4(1H,3H)-pyrimidinedione (126261-80-1,140631-76-1,140631-82-9)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In N,N-dimethyl-formamide; at 80 ℃; for 38h;

DOI:10.1021/jm00088a015

Reference yield: 36.0%

<1S-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester (132294-18-9) + uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6) → <1R-(1α,2β,3α)>-1-<2,3-bis<(benzoyloxy)methyl>cyclobutyl>-2,4(1H,3H)-pyrimidinedione (140631-82-9)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In N,N-dimethyl-formamide; at 80 ℃; for 38h;

DOI:10.1021/jm00088a015

Reference yield: 92.0%

(1α,2β,3α)-1-<2,3-bis-<(benzoyloxy)methyl>cyclobutyl>-2,4(1H,3H)-pyrimidinedione (126261-80-1,140631-76-1,140631-82-9) → (1α,2β,3α)-1-<2,3-bis-(hydroxymethyl)cyclobutyl>-2,4(1H,3H)-pyrimidinedione (126298-54-2,126452-00-4,130464-62-9,140631-83-0)

Guidance literature:

With sodium methylate; In methanol; at 40 ℃; for 3h;

DOI:10.1021/jm00088a015

upstream raw materials:

<1S-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

uracil

(1α,2β,3β)-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol, dibenzoate ester

Downstream raw materials:

(1α,2β,3α)-1-<2,3-bis-(hydroxymethyl)cyclobutyl>-2,4(1H,3H)-pyrimidinedione