4'-(2-Butyl-4-chloro-5-methoxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carbonyl chloride

Base Information

Chemical Name:4'-(2-Butyl-4-chloro-5-methoxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carbonyl chloride
CAS No.:114772-74-6
Molecular Formula:C₂₃H₂₄Cl₂N₂O₂
Molecular Weight:431.362
Hs Code.:

Synonyms:4'-(2-Butyl-4-chloro-5-methoxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carbonyl chloride

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Chemical Property of 4'-(2-Butyl-4-chloro-5-methoxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carbonyl chloride

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Technology Process of 4'-(2-Butyl-4-chloro-5-methoxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carbonyl chloride

There total 14 articles about 4'-(2-Butyl-4-chloro-5-methoxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114799-01-8
2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloro-5-(methoxymethyl)imidazole

: 114772-74-6
4'-(2-Butyl-4-chloro-5-methoxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carbonyl chloride

Guidance literature:: With thionyl chloride; In chloroform; for 2.5h; Heating;
DOI:10.1021/jm00112a031

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 114772-74-6
4'-(2-Butyl-4-chloro-5-methoxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 9 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

6: 97 percent / thionyl chloride / CHCl₃ / 4 h / 25 °C

7: 4.77 g / Na / 18 h / 25 °C

8: 0.5 N KOH / methanol; H₂O / 22 h / Heating

9: SOCl₂ / CHCl₃ / 2.5 h / Heating

With hydrogenchloride; potassium hydroxide; N-Bromosuccinimide; thionyl chloride; sodium methylate; sodium; acetyl chloride; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; chloroform; water;
DOI:10.1021/jm00112a031

Reference yield:

: 624-31-7
4-tolyl iodide

: 114772-74-6
4'-(2-Butyl-4-chloro-5-methoxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 7 steps

1: 11 percent / Cu / 1 h / 210 °C

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

4: 97 percent / thionyl chloride / CHCl₃ / 4 h / 25 °C

5: 4.77 g / Na / 18 h / 25 °C

6: 0.5 N KOH / methanol; H₂O / 22 h / Heating

7: SOCl₂ / CHCl₃ / 2.5 h / Heating

With potassium hydroxide; N-Bromosuccinimide; thionyl chloride; sodium methylate; sodium; copper; dibenzoyl peroxide; In methanol; tetrachloromethane; chloroform; water;
DOI:10.1021/jm00112a031