(E)-4-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)benzyl)morpholine

Base Information

Chemical Name:(E)-4-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)benzyl)morpholine
CAS No.:1010104-38-7
Molecular Formula:C₁₉H₂₈BNO₃
Molecular Weight:329.247
Hs Code.:

Synonyms:(E)-4-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)benzyl)morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-4-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)benzyl)morpholine

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Technology Process of (E)-4-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)benzyl)morpholine

There total 2 articles about (E)-4-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)benzyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75927-49-0
pinacol vinylboronate

: 364793-82-8
4-(3-bromobenzyl)morpholine

: 1010104-38-7
(E)-4-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)benzyl)morpholine

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; In toluene; for 3h; Inert atmosphere; Heating;
DOI:10.1016/j.bmcl.2020.126957

Reference yield:

: 1247001-39-3
4-(3-ethynylbenzyl)morpholine

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 1010104-38-7
(E)-4-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)benzyl)morpholine

Guidance literature:: With ruthenium(H)(Cl)(CO)(triphenylphosphine)3; In toluene; at 50 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm5005336

Reference yield: 77.0%

: 1010104-38-7
(E)-4-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)benzyl)morpholine

: 5-bromo-3-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-2-methyl-N-((1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolin-4-yl)methyl)benzamide

: (E)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methyl-N-((1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolin-4-yl)methyl)-5-(3-(morpholinomethyl)styryl)benzamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; for 6h; Heating; Inert atmosphere;
DOI:10.1016/j.bmcl.2020.126957