2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid tert-butyl ester

Base Information

Chemical Name:2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid tert-butyl ester
CAS No.:164412-85-5
Molecular Formula:C₂₆H₃₃N₃O₄S₂
Molecular Weight:515.698
Hs Code.:

Synonyms:2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid tert-butyl ester

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Chemical Property of 2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid tert-butyl ester

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Technology Process of 2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid tert-butyl ester

There total 12 articles about 2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 71432-55-8
2-tert-butyl-1,3-diisopropylisourea

: 164412-48-0
2-Butyl-5-methylsulfanyl-3-(2'-sulfamoylbiphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid

: 164412-85-5
2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid tert-butyl ester

Guidance literature:: In dichloromethane; for 10h; Ambient temperature;
DOI:10.1021/jm00013a013

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 164412-85-5
2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / aq. Na₂CO₃, triphenylphosphine, palladium acetate / ethanol; toluene / 4 h / Heating

2: 64 percent / N-bromosuccinimide, benzoyl peroxide / chlorobenzene / 1 h / 120 °C

3: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

4: 81 percent / conc. HCl / ethanol / 2 h / Heating

5: 62 percent / 2N NaOH / ethanol / 36 h / Ambient temperature

6: 85 percent / CH₂Cl₂ / 10 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; palladium diacetate; sodium carbonate; potassium carbonate; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl-formamide; chlorobenzene; toluene;
DOI:10.1021/jm00013a013

Reference yield:

: 92748-09-9
2-bromobenzene-1-sulfonamide

: 164412-85-5
2-Butyl-5-methylsulfanyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / dimethylformamide / 2 h / Ambient temperature

2: 93 percent / aq. Na₂CO₃, triphenylphosphine, palladium acetate / ethanol; toluene / 4 h / Heating

3: 64 percent / N-bromosuccinimide, benzoyl peroxide / chlorobenzene / 1 h / 120 °C

4: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

5: 81 percent / conc. HCl / ethanol / 2 h / Heating

6: 62 percent / 2N NaOH / ethanol / 36 h / Ambient temperature

7: 85 percent / CH₂Cl₂ / 10 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; palladium diacetate; sodium carbonate; potassium carbonate; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl-formamide; chlorobenzene; toluene;
DOI:10.1021/jm00013a013