3-[2-(3-aminophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

Base Information

Chemical Name:3-[2-(3-aminophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS No.:78660-84-1
Molecular Formula:C₁₆H₁₄N₂O₃
Molecular Weight:282.299
Hs Code.:
Mol file:78660-84-1.mol

Synonyms:3-[2-(3-Amino-phenyl)-2-oxo-ethyl]-3-hydroxy-1,3-dihydro-indol-2-one

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Chemical Property of 3-[2-(3-aminophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

Chemical Property:

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Technology Process of 3-[2-(3-aminophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

There total 3 articles about 3-[2-(3-aminophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 99-03-6
1-(3-aminophenyl)ethanone

: 78660-84-1
3-[2-(3-Amino-phenyl)-2-oxo-ethyl]-3-hydroxy-1,3-dihydro-indol-2-one

Guidance literature:: ammonium hydroxide; In ethanol; Ambient temperature;
DOI:10.1007/BF00758458

Reference yield:

: 42366-35-8,1769-41-1
hydroxyimino-N-phenylacetamide

: 78660-84-1
3-[2-(3-Amino-phenyl)-2-oxo-ethyl]-3-hydroxy-1,3-dihydro-indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 1.25 h / 60 - 80 °C

2: ethanol / 20 °C

With sulfuric acid; In ethanol;
DOI:10.1016/j.ejmech.2017.12.043

Reference yield:

: 62-53-3
aniline

: 78660-84-1
3-[2-(3-Amino-phenyl)-2-oxo-ethyl]-3-hydroxy-1,3-dihydro-indol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium sulfate / water / 35 °C

1.2: 2 h / 80 °C

2.1: sulfuric acid / 1.25 h / 60 - 80 °C

3.1: ethanol / 20 °C

With sulfuric acid; sodium sulfate; In ethanol; water;
DOI:10.1016/j.ejmech.2017.12.043