(E)-1-(3-Fluoro-6,11-dihydrodibenzothiepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine oxalate

Base Information

Chemical Name:(E)-1-(3-Fluoro-6,11-dihydrodibenzothiepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine oxalate
CAS No.:139305-30-9
Molecular Formula:C₂H₂O₄*C₂₇H₂₇FN₂S
Molecular Weight:520.625
Hs Code.:

(E)-1-(3-Fluoro-6,11-dihydrodibenzo<b,e>thiepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine oxalate

Synonyms:(E)-1-(3-Fluoro-6,11-dihydrodibenzothiepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine oxalate

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Chemical Property of (E)-1-(3-Fluoro-6,11-dihydrodibenzothiepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine oxalate

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Technology Process of (E)-1-(3-Fluoro-6,11-dihydrodibenzothiepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine oxalate

There total 6 articles about (E)-1-(3-Fluoro-6,11-dihydrodibenzothiepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 18903-01-0,114312-65-1,87179-40-6
trans-1-cinnamylpiperazine

: 5-Chloro-8-fluoro-5,11-dihydro-10-thia-dibenzo[a,d]cycloheptene

: 139305-30-9
(E)-1-(3-Fluoro-6,11-dihydrodibenzothiepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine oxalate

Guidance literature:: In dichloromethane; for 1h; Ambient temperature;
DOI:10.1248/cpb.39.2564

Reference yield:

: 87-41-2
2-benzofuran-1(3H)-one

: 139305-30-9
(E)-1-(3-Fluoro-6,11-dihydrodibenzothiepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine oxalate

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 2 h / 100 °C

2: 32 percent / polyphosphoric acid / 3 h / 100 °C

3: NaBH₄ / methanol / 0.33 h / 0 °C

4: SOCl₂ / 0.17 h / Ambient temperature

5: 39 percent / CH₂Cl₂ / 1 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; PPA; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2564

Reference yield:

: 2557-77-9
3-fluorothiophenol

: 139305-30-9
(E)-1-(3-Fluoro-6,11-dihydrodibenzothiepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine oxalate

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 2 h / 100 °C

2: 32 percent / polyphosphoric acid / 3 h / 100 °C

3: NaBH₄ / methanol / 0.33 h / 0 °C

4: SOCl₂ / 0.17 h / Ambient temperature

5: 39 percent / CH₂Cl₂ / 1 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; PPA; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2564