4-(N-benzyloxy-N-tert-butoxycarbonylamino)-butyric acid benzyl ester

Base Information

• Chemical Name: 4-(N-benzyloxy-N-tert-butoxycarbonylamino)-butyric acid benzyl ester
• CAS No.: 608527-28-2
• Molecular Formula: C₂₃H₂₉NO₅
• Molecular Weight: 399.487
• Mol file: 608527-28-2.mol

Synonyms:4-(N-benzyloxy-N-tert-butoxycarbonylamino)-butyric acid benzyl ester

Chemical Property of 4-(N-benzyloxy-N-tert-butoxycarbonylamino)-butyric acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(N-benzyloxy-N-tert-butoxycarbonylamino)-butyric acid benzyl ester

There total 1 articles about 4-(N-benzyloxy-N-tert-butoxycarbonylamino)-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butyl N-(benzyloxy)carbamate (79722-21-7) + benzyl 4-bromobutanoate (126430-46-4) → 4-(N-benzyloxy-N-tert-butoxycarbonylamino)-butyric acid benzyl ester (608527-28-2)

Guidance literature:

tert-butyl N-(benzyloxy)carbamate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 0.5h;

benzyl 4-bromobutanoate; With sodium iodide; In N,N-dimethyl-formamide; at 50 ℃; for 1.5h;

DOI:10.1515/znb-2003-0517

Reference yield: 80.0%

4-(N-benzyloxy-N-tert-butoxycarbonylamino)-butyric acid benzyl ester (608527-28-2) → 4-benzyloxyamino-butyric acid benzyl ester (608527-29-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1515/znb-2003-0517

Reference yield:

4-(N-benzyloxy-N-tert-butoxycarbonylamino)-butyric acid benzyl ester (608527-28-2) → 4-[N-benzyloxy-N-(4-phenoxy-benzoyl)amino]-butyric acid benzyl ester (608527-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / TFA / CH₂Cl₂ / 1 h / 20 °C

2: 93 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1515/znb-2003-0517

upstream raw materials:

tert-butyl N-(benzyloxy)carbamate

benzyl 4-bromobutanoate

Downstream raw materials:

4-benzyloxyamino-butyric acid benzyl ester

4-(N-benzyloxy-N-formylamino)-butyric acid benzyl ester

4-(N-acetyl-N-benzyloxyamino)-butyric acid benzyl ester

4-(N-benzyloxy-N-isobutyrylamino)-butyric acid benzyl ester