(R)-2-amino-3-(4-methoxyphenyl)-1-(3-butyloxy-3-o-tolylazetidin-1-yl)propan-1-one hydrochloride

Base Information

• Chemical Name: (R)-2-amino-3-(4-methoxyphenyl)-1-(3-butyloxy-3-o-tolylazetidin-1-yl)propan-1-one hydrochloride
• CAS No.: 1225439-20-2
• Molecular Formula: C₂₄H₃₂N₂O₃*ClH
• Molecular Weight: 432.991
• Mol file: 1225439-20-2.mol

Synonyms:(R)-2-amino-3-(4-methoxyphenyl)-1-(3-butyloxy-3-o-tolylazetidin-1-yl)propan-1-one hydrochloride

Chemical Property of (R)-2-amino-3-(4-methoxyphenyl)-1-(3-butyloxy-3-o-tolylazetidin-1-yl)propan-1-one hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-amino-3-(4-methoxyphenyl)-1-(3-butyloxy-3-o-tolylazetidin-1-yl)propan-1-one hydrochloride

There total 1 articles about (R)-2-amino-3-(4-methoxyphenyl)-1-(3-butyloxy-3-o-tolylazetidin-1-yl)propan-1-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

tert-butyl [(R)-2-(3-butoxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-oxoethyl]carbamate (1225439-21-3) → (R)-2-amino-3-(4-methoxyphenyl)-1-(3-butyloxy-3-o-tolylazetidin-1-yl)propan-1-one hydrochloride (1225439-20-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h;

Reference yield: 86.0%

3-(5-methyl-3H-imidazol-4-yl)propanoic acid (148206-97-7) + (R)-2-amino-3-(4-methoxyphenyl)-1-(3-butyloxy-3-o-tolylazetidin-1-yl)propan-1-one hydrochloride (1225439-20-2) → N-[(R)-2-(3-butoxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-oxoethyl]-3-(5-methyl-3H-imidazol-4-yl)propionamide (1225438-45-8)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 23.0%

3-(1-methyl-1H-imidazol-4-yl)propanoic acid hydrochloride (1225439-53-1) + (R)-2-amino-3-(4-methoxyphenyl)-1-(3-butyloxy-3-o-tolylazetidin-1-yl)propan-1-one hydrochloride (1225439-20-2) → N-[(R)-2-(3-butoxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-oxoethyl]-3-(1-methyl-1H-imidazol-4-yl)propionamide (1225438-73-2)

Guidance literature:

3-(1-methyl-1H-imidazol-4-yl)propanoic acid hydrochloride; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

(R)-2-amino-3-(4-methoxyphenyl)-1-(3-butyloxy-3-o-tolylazetidin-1-yl)propan-1-one hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

upstream raw materials:

tert-butyl [(R)-2-(3-butoxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-oxoethyl]carbamate

Downstream raw materials:

N-[(R)-2-(3-butoxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-oxoethyl]-3-(1H-[1,2,3]triazol-4-yl)propionamide

N-[(R)-2-(3-butoxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-oxoethyl]-3-(5-methyl-3H-imidazol-4-yl)propionamide

N-[(R)-2-(3-butoxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-oxoethyl]-3-(1-methyl-1H-imidazol-4-yl)propionamide

(S)-N-[(R)-2-(3-butoxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-oxoethyl]-2-hydroxy-3-(1H-imidazol-4-yl)propionamide