[4-(3-benzyl-2,5-dioxo-4-phenyl-imidazolidin-1-yl)-phenyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[4-(3-benzyl-2,5-dioxo-4-phenyl-imidazolidin-1-yl)-phenyl]-carbamic acid benzyl ester
CAS No.:1118749-86-2
Molecular Formula:C₃₀H₂₅N₃O₄
Molecular Weight:491.546
Hs Code.:

Synonyms:[4-(3-benzyl-2,5-dioxo-4-phenyl-imidazolidin-1-yl)-phenyl]-carbamic acid benzyl ester

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Chemical Property of [4-(3-benzyl-2,5-dioxo-4-phenyl-imidazolidin-1-yl)-phenyl]-carbamic acid benzyl ester

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Technology Process of [4-(3-benzyl-2,5-dioxo-4-phenyl-imidazolidin-1-yl)-phenyl]-carbamic acid benzyl ester

There total 4 articles about [4-(3-benzyl-2,5-dioxo-4-phenyl-imidazolidin-1-yl)-phenyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 4870-65-9,31302-84-8
2-bromophenylacetic acid

: 3173-56-6
benzyl isothiocyanate

: 4-CbzNHC₆H₄N₃

: 1118749-86-2
[4-(3-benzyl-2,5-dioxo-4-phenyl-imidazolidin-1-yl)-phenyl]-carbamic acid benzyl ester

Guidance literature:: 4-CbzNHC₆H₄N₃; With triphenylphosphine; In dichloromethane; at 20 ℃;

benzyl isothiocyanate; In dichloromethane; for 3h;

2-bromophenylacetic acid; Further stages;
DOI:10.1055/s-0028-1087352

Reference yield:

: 4870-65-9,31302-84-8
2-bromophenylacetic acid

: 1415959-16-8
C₂₂H₁₉N₃O₂

: 1118749-86-2
[4-(3-benzyl-2,5-dioxo-4-phenyl-imidazolidin-1-yl)-phenyl]-carbamic acid benzyl ester

Guidance literature:: 2-bromophenylacetic acid; C₂₂H₁₉N₃O₂; With 2,4,6-trimethyl-pyridine; In dichloromethane; at 20 ℃;

With sodium hydroxide; In dichloromethane; water; at 0 ℃; regioselective reaction;
DOI:10.1039/c2ob26498f

Reference yield:

: 3173-56-6
benzyl isothiocyanate

: 1118749-86-2
[4-(3-benzyl-2,5-dioxo-4-phenyl-imidazolidin-1-yl)-phenyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / dichloromethane

2.1: 2,4,6-trimethyl-pyridine / dichloromethane / 20 °C

2.2: 0 °C

With 2,4,6-trimethyl-pyridine; triphenylphosphine; In dichloromethane; 1.1: |Staudinger Azide Reduction / 2.2: |Schotten-Baumann Reaction;
DOI:10.1039/c2ob26498f