(S)-2-Benzyloxycarbonylamino-propionic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-propionic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester
CAS No.:439589-15-8
Molecular Formula:C₃₃H₅₀N₂O₆S
Molecular Weight:602.836
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-propionic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-propionic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-propionic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 6 articles about (S)-2-Benzyloxycarbonylamino-propionic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 99295-72-4
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-hydroxybicyclo[2.2.1]heptane-1-methanesulfonamide

: 133010-19-2
(S)-N-cbz-alanoyl fluoride

: 439589-15-8
(S)-2-Benzyloxycarbonylamino-propionic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jo025571j

Reference yield:

: 439589-14-7
(S)-2-Benzyloxycarbonylamino-3-phenyl-propionic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 439589-15-8
(S)-2-Benzyloxycarbonylamino-propionic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: H₂ / Pd/C / methanol / 1 h / 20 °C / 1551.49 Torr

2.1: methanol / 2 h / 20 °C

2.2: NaBH₃CN; ZnCl₂ / methanol / 2 h / 20 °C

3.1: 94 percent / propylene oxide / tetrahydrofuran / 20 °C

4.1: 55 percent / BTPP / CH₂Cl₂ / 24 h / 20 °C

5.1: 2 N NaOH / methanol / 20 °C

5.2: HCl / H₂O / pH 3

6.1: 80 percent / DMAP / CH₂Cl₂ / 1 h / 20 °C

With dmap; sodium hydroxide; hydrogen; tert-butylimino-tri(pyrrolidino)phosphorane; methyloxirane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo025571j

Reference yield:

: (S)-2-Amino-3-phenyl-propionic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 439589-15-8
(S)-2-Benzyloxycarbonylamino-propionic acid (1R,2S,4S)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 2 h / 20 °C

1.2: NaBH₃CN; ZnCl₂ / methanol / 2 h / 20 °C

2.1: 94 percent / propylene oxide / tetrahydrofuran / 20 °C

3.1: 55 percent / BTPP / CH₂Cl₂ / 24 h / 20 °C

4.1: 2 N NaOH / methanol / 20 °C

4.2: HCl / H₂O / pH 3

5.1: 80 percent / DMAP / CH₂Cl₂ / 1 h / 20 °C

With dmap; sodium hydroxide; tert-butylimino-tri(pyrrolidino)phosphorane; methyloxirane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo025571j