dimethyl 4-[1-benzyloxymethyl-7-methoxymethoxyindol-3-yl]-3-(4-isopropoxyphenyl)-1-[2-(4-isopropoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate

Base Information

• Chemical Name: dimethyl 4-[1-benzyloxymethyl-7-methoxymethoxyindol-3-yl]-3-(4-isopropoxyphenyl)-1-[2-(4-isopropoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate
• CAS No.: 1206199-67-8
• Molecular Formula: C₄₆H₅₀N₂O₉
• Molecular Weight: 774.911
• Mol file: 1206199-67-8.mol

Synonyms:dimethyl 4-[1-benzyloxymethyl-7-methoxymethoxyindol-3-yl]-3-(4-isopropoxyphenyl)-1-[2-(4-isopropoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate

Chemical Property of dimethyl 4-[1-benzyloxymethyl-7-methoxymethoxyindol-3-yl]-3-(4-isopropoxyphenyl)-1-[2-(4-isopropoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 4-[1-benzyloxymethyl-7-methoxymethoxyindol-3-yl]-3-(4-isopropoxyphenyl)-1-[2-(4-isopropoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate

There total 1 articles about dimethyl 4-[1-benzyloxymethyl-7-methoxymethoxyindol-3-yl]-3-(4-isopropoxyphenyl)-1-[2-(4-isopropoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-benzyloxymethyl-7-methoxymethoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-indole (1206199-65-6) + dimethyl 3-(4-isopropoxyphenyl)-1-[2-(4-isopropoxyphenyl)ethyl]-4-(trifluoromethanesulfonyloxy)pyrrole-2,5-dicarboxylate (1206199-53-2) → dimethyl 4-[1-benzyloxymethyl-7-methoxymethoxyindol-3-yl]-3-(4-isopropoxyphenyl)-1-[2-(4-isopropoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate (1206199-67-8)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 95 ℃; for 19h; Inert atmosphere;

DOI:10.1271/bbb.90111

Reference yield:

dimethyl 4-[1-benzyloxymethyl-7-methoxymethoxyindol-3-yl]-3-(4-isopropoxyphenyl)-1-[2-(4-isopropoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate (1206199-67-8) → C44H46N2O9 (1206199-69-0)

Guidance literature:

dimethyl 4-[1-benzyloxymethyl-7-methoxymethoxyindol-3-yl]-3-(4-isopropoxyphenyl)-1-[2-(4-isopropoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate; With water; sodium hydroxide; In ethanol; at 90 ℃; for 17h;

With hydrogenchloride; In water; pH=2 - 3; Cooling with ice;

DOI:10.1271/bbb.90111

upstream raw materials:

1-benzyloxymethyl-7-methoxymethoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-indole

dimethyl 3-(4-isopropoxyphenyl)-1-[2-(4-isopropoxyphenyl)ethyl]-4-(trifluoromethanesulfonyloxy)pyrrole-2,5-dicarboxylate

Downstream raw materials:

C₄₄H₄₆N₂O₉