3-bromo-5-[6-(5-{3-bromo-5-[(hexyloxy)methyl]phenyl}pyridin-2-yl)pyridin-3-yl]benzyl methacrylate

Base Information

Chemical Name:3-bromo-5-[6-(5-{3-bromo-5-[(hexyloxy)methyl]phenyl}pyridin-2-yl)pyridin-3-yl]benzyl methacrylate
CAS No.:851605-53-3
Molecular Formula:C₃₄H₃₄Br₂N₂O₃
Molecular Weight:678.464
Hs Code.:

Synonyms:3-bromo-5-[6-(5-{3-bromo-5-[(hexyloxy)methyl]phenyl}pyridin-2-yl)pyridin-3-yl]benzyl methacrylate

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Chemical Property of 3-bromo-5-[6-(5-{3-bromo-5-[(hexyloxy)methyl]phenyl}pyridin-2-yl)pyridin-3-yl]benzyl methacrylate

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Technology Process of 3-bromo-5-[6-(5-{3-bromo-5-[(hexyloxy)methyl]phenyl}pyridin-2-yl)pyridin-3-yl]benzyl methacrylate

There total 9 articles about 3-bromo-5-[6-(5-{3-bromo-5-[(hexyloxy)methyl]phenyl}pyridin-2-yl)pyridin-3-yl]benzyl methacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 920-46-7,26937-45-1
Methacryloyl chloride

: 851605-52-2
{3-bromo-5-[6-(5-{3-bromo-5-[(hexyloxy)methyl]phenyl}pyridin-2-yl)pyridin-3-yl]phenyl}methanol

: 851605-53-3
3-bromo-5-[6-(5-{3-bromo-5-[(hexyloxy)methyl]phenyl}pyridin-2-yl)pyridin-3-yl]benzyl methacrylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 20h;
DOI:10.1002/ejoc.200400744

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 851605-53-3
3-bromo-5-[6-(5-{3-bromo-5-[(hexyloxy)methyl]phenyl}pyridin-2-yl)pyridin-3-yl]benzyl methacrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: nBuLi / diethyl ether; hexane / 3 h / -78 °C

1.2: 75 percent / 1,2-diiodoethane / diethyl ether; hexane / -78 - 20 °C

2.1: Bu₄NBr; Na₂CO₃; [Pd(PPh₃)4] / toluene; H₂O / 96 h / Heating

3.1: [Pd(PPh₃)4] / toluene / 120 h

4.1: 93 percent / HCl; water / tetrahydrofuran; methanol / 24 h / 20 °C

5.1: 95 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 h / 0 °C

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetrabutylammomium bromide; water; sodium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; toluene;
DOI:10.1002/ejoc.200400744

Reference yield:

: 73290-22-9
2-bromo-5-iodo-pyridine

: 851605-53-3
3-bromo-5-[6-(5-{3-bromo-5-[(hexyloxy)methyl]phenyl}pyridin-2-yl)pyridin-3-yl]benzyl methacrylate

Guidance literature:: Multi-step reaction with 4 steps

1: Bu₄NBr; Na₂CO₃; [Pd(PPh₃)4] / toluene; H₂O / 96 h / Heating

2: [Pd(PPh₃)4] / toluene / 120 h

3: 93 percent / HCl; water / tetrahydrofuran; methanol / 24 h / 20 °C

4: 95 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 h / 0 °C

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; water; sodium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1002/ejoc.200400744