8-amino-3-(3-methoxy-4-nitrophenyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Base Information

Chemical Name:8-amino-3-(3-methoxy-4-nitrophenyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
CAS No.:755027-95-3
Molecular Formula:C₂₀H₁₆N₄O₄
Molecular Weight:376.371
Hs Code.:

Synonyms:8-amino-3-(3-methoxy-4-nitrophenyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

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Chemical Property of 8-amino-3-(3-methoxy-4-nitrophenyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

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Technology Process of 8-amino-3-(3-methoxy-4-nitrophenyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

There total 6 articles about 8-amino-3-(3-methoxy-4-nitrophenyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 755026-39-2
methyl 2-[(2-amino-4-nitrophenyl)amino]-4-chlorobenzoate

: 755027-95-3
8-amino-3-(3-methoxy-4-nitrophenyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pt/C / methanol / 20 °C

2: TsOH*H₂O / toluene / 48 h / Heating

3: Cy-MAP; CsF / Pd(OAc)2 / 1,2-dimethoxy-ethane; methanol / 12 h / Heating

With hydrogen; toluene-4-sulfonic acid; cesium fluoride; palladium diacetate; platinum on activated charcoal; In methanol; 1,2-dimethoxyethane; toluene; 3: Suzuki reaction;
DOI:10.1021/jm070105d

Reference yield:

: 755026-49-4
methyl 4-chloro-2-[(2,4-diaminophenyl)amino]benzoate

: 755027-95-3
8-amino-3-(3-methoxy-4-nitrophenyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Guidance literature:: Multi-step reaction with 2 steps

1: TsOH*H₂O / toluene / 48 h / Heating

2: Cy-MAP; CsF / Pd(OAc)2 / 1,2-dimethoxy-ethane; methanol / 12 h / Heating

With toluene-4-sulfonic acid; cesium fluoride; palladium diacetate; In methanol; 1,2-dimethoxyethane; toluene; 2: Suzuki reaction;
DOI:10.1021/jm070105d

Reference yield:

: 6627-53-8
1-chloro-3-methoxy-4-nitrobenzene

: 755027-95-3
8-amino-3-(3-methoxy-4-nitrophenyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / PCy₃; KOAc / Pd₂(dba)3 / dioxane / 20 h / 85 °C

2: Cy-MAP; CsF / Pd(OAc)2 / 1,2-dimethoxy-ethane; methanol / 12 h / Heating

With potassium acetate; cesium fluoride; tricyclohexylphosphine; palladium diacetate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; 2: Suzuki reaction;
DOI:10.1021/jm070105d