diethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate

Base Information

• Chemical Name: diethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate
• CAS No.: 259870-78-5
• Molecular Formula: C₁₉H₂₁NO₅
• Molecular Weight: 343.379
• Mol file: 259870-78-5.mol

Synonyms:diethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate

Chemical Property of diethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of diethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate

There total 5 articles about diethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,6-dimethyl-3,5-diethoxycarbonyl-4-(3-hydroxyphenyl)-1,4-dihydropyridine (34148-68-0) → diethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (259870-78-5)

Guidance literature:

In acetonitrile; at 20 ℃; for 0.00833333h; Sonication; Green chemistry;

DOI:10.1007/s11696-018-0666-5

Reference yield:

ethyl acetoacetate (141-97-9) + meta-hydroxybenzaldehyde (100-83-4) → diethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (259870-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / ethanol / Reflux

2: / acetonitrile / 0.01 h / 20 °C / Sonication; Green chemistry

With ammonium acetate; In ethanol; acetonitrile; 1: |Hantzsch Dihydropyridine Synthesis;

DOI:10.1007/s11696-018-0666-5

Reference yield:

→ diethyl 4-(3-hydroxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (259870-78-5)

Guidance literature:

With sulfuric acid; Diazotization;

upstream raw materials:

4-(3-acetoxy-phenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester

2,6-dimethyl-3,5-diethoxycarbonyl-4-(3-hydroxyphenyl)-1,4-dihydropyridine

4-(3-acetoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

ethyl acetoacetate

Downstream raw materials:

diethyl 2,6-dimethyl-4-(m-methoxyphenyl)pyridine-3,5-dicarboxylate

4-(3-methoxy-phenyl)-2,6-dimethyl-nicotinic acid

4-(3-methoxy-phenyl)-2,6-dimethyl-nicotinic acid ethyl ester