[(S)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-((Z)-3-iodo-allyl)-pyrrolidin-2-yl]-methanol

Base Information

Chemical Name:[(S)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-((Z)-3-iodo-allyl)-pyrrolidin-2-yl]-methanol
CAS No.:1026068-36-9
Molecular Formula:C₁₈H₂₆INO₃
Molecular Weight:431.314
Hs Code.:

Synonyms:[(S)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-((Z)-3-iodo-allyl)-pyrrolidin-2-yl]-methanol

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Chemical Property of [(S)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-((Z)-3-iodo-allyl)-pyrrolidin-2-yl]-methanol

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Technology Process of [(S)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-((Z)-3-iodo-allyl)-pyrrolidin-2-yl]-methanol

There total 9 articles about [(S)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-((Z)-3-iodo-allyl)-pyrrolidin-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160360-11-2
(2S)-Methyl 2-((Z)-3-iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carboxylate

: 1026068-36-9
[(S)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-((Z)-3-iodo-allyl)-pyrrolidin-2-yl]-methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -50 ℃; for 6h;
DOI:10.1021/jo00106a023

Reference yield:

: 132564-23-9
2-(3,4-Dimethoxyphenyl)ethyl alcohol p-nitrobenzenesulfonate ester

: 1026068-36-9
[(S)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-((Z)-3-iodo-allyl)-pyrrolidin-2-yl]-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: i-Pr₂NEt / acetonitrile / 12 h / Heating

2: LiAlH₄ / tetrahydrofuran / 6 h / -50 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo00106a023

Reference yield:

: 1026124-76-4
(S)-2-((Z)-3-Iodo-allyl)-pyrrolidine-2-carboxylic acid

: 1026068-36-9
[(S)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-((Z)-3-iodo-allyl)-pyrrolidin-2-yl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaOH / dioxane / 24 h / Ambient temperature

2: methanol; diethyl ether

3: CF₃CO₂H / CH₂Cl₂ / 2 h / Ambient temperature

4: i-Pr₂NEt / acetonitrile / 12 h / Heating

5: LiAlH₄ / tetrahydrofuran / 6 h / -50 °C

With sodium hydroxide; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jo00106a023