3-(2-bromo-4,5-dimetohxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one

Base Information

• Chemical Name: 3-(2-bromo-4,5-dimetohxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one
• CAS No.: 854830-80-1
• Molecular Formula: C₁₉H₁₉BrO₅
• Molecular Weight: 407.261
• Mol file: 854830-80-1.mol

Synonyms:3-(2-bromo-4,5-dimetohxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one

Chemical Property of 3-(2-bromo-4,5-dimetohxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-bromo-4,5-dimetohxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one

There total 2 articles about 3-(2-bromo-4,5-dimetohxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-bromo-4,5-dimethoxybenzaldehyde (5392-10-9) + 1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) → 3-(2-bromo-4,5-dimetohxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one (854830-80-1)

Guidance literature:

With sodium methylate; sodium hydroxide; In ethanol; at 23 ℃; for 18h;

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → 3-(2-bromo-4,5-dimetohxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one (854830-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / methanol / 16 h / 20 °C

2: sodium hydroxide / ethanol / 1 h / Reflux

With bromine; sodium hydroxide; In methanol; ethanol; 2: |Aldol Condensation;

DOI:10.1021/acs.joc.5b02194

Reference yield: 74.0%

3-(2-bromo-4,5-dimetohxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one (854830-80-1) + glycine ethyl ester hydrochloride (623-33-6) → ethyl 3-(2-bromo-4,5-dimethoxyphenyl)-5-(3,4-dimethoxyphenyl)-4-iodo-1H-pyrrole-2-carboxylate

Guidance literature:

3-(2-bromo-4,5-dimetohxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one; glycine ethyl ester hydrochloride; With pyridine; for 24h; Reflux;

With copper diacetate; In pyridine; for 4h; Reflux;

With N-iodo-succinimide; In acetonitrile; at 70 ℃; for 6h;

DOI:10.1021/acs.joc.5b02194

upstream raw materials:

2-bromo-4,5-dimethoxybenzaldehyde

1-(3,4-dimethoxyphenyl)ethanone

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

C₁₅H₁₁BrO₅

14-(3,4-dihydroxyphenyl)-2,3,11,12-tetrahydroxy-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one