(R)-9-[2-(pivaloyloxymethyl)-(isopropoxycarbonyloxymethyl)phosphonoylmethoxypropyl]adenine p-toluenesulfonate

Base Information

Chemical Name:(R)-9-[2-(pivaloyloxymethyl)-(isopropoxycarbonyloxymethyl)phosphonoylmethoxypropyl]adenine p-toluenesulfonate
CAS No.:1354647-85-0
Molecular Formula:C₇H₈O₃S*C₂₁H₃₄N₅O₈P
Molecular Weight:687.708
Hs Code.:

Synonyms:(R)-9-[2-(pivaloyloxymethyl)-(isopropoxycarbonyloxymethyl)phosphonoylmethoxypropyl]adenine p-toluenesulfonate

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Chemical Property of (R)-9-[2-(pivaloyloxymethyl)-(isopropoxycarbonyloxymethyl)phosphonoylmethoxypropyl]adenine p-toluenesulfonate

Chemical Property:

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Technology Process of (R)-9-[2-(pivaloyloxymethyl)-(isopropoxycarbonyloxymethyl)phosphonoylmethoxypropyl]adenine p-toluenesulfonate

There total 4 articles about (R)-9-[2-(pivaloyloxymethyl)-(isopropoxycarbonyloxymethyl)phosphonoylmethoxypropyl]adenine p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-9-[2-(pivaloyloxymethyl)-((isopropoxycarbonyloxymethyl)phosphonoylmethoxy)propyl]adenine

: 104-15-4
toluene-4-sulfonic acid

: 1354647-85-0
(R)-9-[2-(pivaloyloxymethyl)-(isopropoxycarbonyloxymethyl)phosphonoylmethoxypropyl]adenine p-toluenesulfonate

Guidance literature:: In tetrahydrofuran; methanol; at 0 ℃;

Reference yield:

: 14047-28-0,712-00-5
(R)-9-(2-hydroxypropyl)adenine

: 1354647-85-0
(R)-9-[2-(pivaloyloxymethyl)-(isopropoxycarbonyloxymethyl)phosphonoylmethoxypropyl]adenine p-toluenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 60 °C

2: potassium iodide; chloro-trimethyl-silane / acetonitrile / 4 h / 70 °C

3: benzyl tri-n-butylammonium bromide; triethylamine / 1-methyl-pyrrolidin-2-one / 8 h / 50 - 55 °C

4: benzyl tri-n-butylammonium bromide; triethylamine / 1-methyl-pyrrolidin-2-one / 8 h / 50 - 55 °C

5: tetrahydrofuran; methanol / 2 h / 0 °C

With chloro-trimethyl-silane; benzyl tri-n-butylammonium bromide; triethylamine; potassium iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 180587-75-1
(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

: 1354647-85-0
(R)-9-[2-(pivaloyloxymethyl)-(isopropoxycarbonyloxymethyl)phosphonoylmethoxypropyl]adenine p-toluenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium iodide; chloro-trimethyl-silane / acetonitrile / 4 h / 70 °C

2: benzyl tri-n-butylammonium bromide; triethylamine / 1-methyl-pyrrolidin-2-one / 8 h / 50 - 55 °C

3: benzyl tri-n-butylammonium bromide; triethylamine / 1-methyl-pyrrolidin-2-one / 8 h / 50 - 55 °C

4: tetrahydrofuran; methanol / 2 h / 0 °C

With chloro-trimethyl-silane; benzyl tri-n-butylammonium bromide; triethylamine; potassium iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; acetonitrile;