(1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methyl-cyclohexanol

Base Information

Chemical Name:(1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methyl-cyclohexanol
CAS No.:758719-67-4
Molecular Formula:C₄₃H₆₄O₃Si
Molecular Weight:657.065
Hs Code.:

(1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methyl-cyclohexanol

Synonyms:(1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methyl-cyclohexanol

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Chemical Property of (1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methyl-cyclohexanol

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Technology Process of (1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methyl-cyclohexanol

There total 18 articles about (1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methyl-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₇H₇₂O₄Si

: 758719-67-4
(1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methyl-cyclohexanol

: 758719-68-5
(1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-2-methyl-cyclohexanol

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; water; at 55 - 60 ℃; for 4h;

Reference yield:

: 758719-37-8
1-[(1S,3R,4R,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-bicyclo[3.1.0]hex-1-yl]-2-[(1R,3aS,7aR)-1-[(R)-5-(1-ethoxy-ethoxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol

: 758719-67-4
(1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methyl-cyclohexanol

: 758719-68-5
(1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-2-methyl-cyclohexanol

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; water; at 55 - 60 ℃; for 4h;
DOI:10.1002/ejoc.200500289

Reference yield:

: 757240-15-6
(1R,5R)-5-Hydroxy-4-methyl-cyclohex-3-enecarboxylic acid methyl ester

: 758719-67-4
(1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1.68 g / imidazole; DMAP / dimethylformamide / 10 h / 20 °C

2.1: BH₃ / tetrahydrofuran / 2.5 h / 0 °C

2.2: 35 percent / H₂O₂; NaHCO₃ / tetrahydrofuran / 0.5 h

3.1: 81 percent / PPh₃; DIAD / tetrahydrofuran / 24 h / 20 °C

4.1: 95 percent / K₂CO₃ / methanol / 6 h / 20 °C

5.1: 94 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

6.1: 71 percent / tBuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 0.5 h / 45 - 50 °C

7.1: LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

8.1: NMO; TPAP / CH₂Cl₂ / 0.5 h / 20 °C

9.1: 48 percent / tBuLi / tetrahydrofuran / 2.5 h / -78 - -10 °C

10.1: 38 mg / PTSA / dioxane; H₂O / 4 h / 55 - 60 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; N-methyl-2-indolinone; tetrapropylammonium perruthennate; di-isopropyl azodicarboxylate; borane; potassium tert-butylate; tert.-butyl lithium; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3.1: Mitsunobu inversion;
DOI:10.1002/ejoc.200500289