(benzyloxycarbonyl)-L-prolyl-L-tryptophylglycinamide

Base Information

Chemical Name:(benzyloxycarbonyl)-L-prolyl-L-tryptophylglycinamide
CAS No.:75511-59-0
Molecular Formula:C₂₆H₂₉N₅O₅
Molecular Weight:491.547
Hs Code.:

Synonyms:(benzyloxycarbonyl)-L-prolyl-L-tryptophylglycinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (benzyloxycarbonyl)-L-prolyl-L-tryptophylglycinamide

Chemical Property:

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Technology Process of (benzyloxycarbonyl)-L-prolyl-L-tryptophylglycinamide

There total 5 articles about (benzyloxycarbonyl)-L-prolyl-L-tryptophylglycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16624-64-9
N-α-carbobenzoxy-L-tyrosine p-nitrophenyl ester

: 75511-59-0
(benzyloxycarbonyl)-L-prolyl-L-tryptophylglycinamide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / aq. NaOH, pyridine / 0.5 h

2: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

3: NH₃ / tetrahydrofuran / 0.5 h / -15 °C

4: H₂ / 10percent Pd/C / aq. ethanol / 3 h

5: 1-hydroxybenzotriazole monohydrate / dimethylformamide

With 4-methyl-morpholine; pyridine; sodium hydroxide; ammonia; hydrogen; 1-hydroxybenzotriazol-hydrate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00185a025

Reference yield:

: C₂₆H₂₉N₃O₇

: 75511-59-0
(benzyloxycarbonyl)-L-prolyl-L-tryptophylglycinamide

Guidance literature:: Multi-step reaction with 3 steps

1: NH₃ / tetrahydrofuran / 0.5 h / -15 °C

2: H₂ / 10percent Pd/C / aq. ethanol / 3 h

3: 1-hydroxybenzotriazole monohydrate / dimethylformamide

With ammonia; hydrogen; 1-hydroxybenzotriazol-hydrate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00185a025

Reference yield:

: 68996-89-4
benzyl N-[(1S)-2-[(2-amino-2-oxoethyl)amino]-1-(1H-indol-2-ylmethyl)-2-oxoethyl]carbamate

: 75511-59-0
(benzyloxycarbonyl)-L-prolyl-L-tryptophylglycinamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / aq. ethanol / 3 h

2: 1-hydroxybenzotriazole monohydrate / dimethylformamide

With hydrogen; 1-hydroxybenzotriazol-hydrate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00185a025