THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE

Base Information

• Chemical Name: THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE
• CAS No.: 101257-38-9
• Molecular Formula: C4H5 N3 O S
• Molecular Weight: 143.17
• Hs Code.: 2934100090
• Mol file: 101257-38-9.mol

Synonyms:Idv 132

Chemical Property of THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE

Chemical Property:

• Melting Point: 143-144 °C
• Refractive Index: 1.625
• Boiling Point: °Cat760mmHg
• PKA: 11.08±0.10(Predicted)
• Flash Point: °C
• PSA: 96.25000
• Density: 1.436g/cm³
• LogP: 0.83780
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

Thiazole-4-carboxylic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE

There total 2 articles about THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl thiazole-4-carboxylate (14527-43-6) → thiazole-4-carbohydrazide (101257-38-9)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; Reflux;

DOI:10.1021/acs.inorgchem.9b02993

Reference yield:

1,1-dimethylethyl 2-(1,3-thiazol-4-ylcarbonyl)hydrazinecarboxylate (1254073-60-3) → thiazole-4-carbohydrazide (101257-38-9)

Guidance literature:

1,1-dimethylethyl 2-(1,3-thiazol-4-ylcarbonyl)hydrazinecarboxylate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;

With ammonia; In dichloromethane;

Reference yield: 76.0%

thiazole-4-carbohydrazide (101257-38-9) + (1-phenyl-propylidene)-p-tolyl-amine → 4-(5-phenyl-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thiazole

Guidance literature:

In butan-1-ol; at 108 ℃; for 72h;

DOI:10.1021/acs.inorgchem.9b02993

upstream raw materials:

ethyl thiazole-4-carboxylate

1,1-dimethylethyl 2-(1,3-thiazol-4-ylcarbonyl)hydrazinecarboxylate

Downstream raw materials:

N-benzenesulfonyl-N'-(thiazole-4-carbonyl)-hydrazine