methyl [5-(benzoylamino)-2-hydroxy-6-oxo-2-(trifluoromethyl)-3,6-dihydropyridin-1(2H)-yl]acetate

Base Information

• Chemical Name: methyl [5-(benzoylamino)-2-hydroxy-6-oxo-2-(trifluoromethyl)-3,6-dihydropyridin-1(2H)-yl]acetate
• CAS No.: 1305340-10-6
• Molecular Formula: C₁₆H₁₅F₃N₂O₅
• Molecular Weight: 372.301
• Mol file: 1305340-10-6.mol

Synonyms:methyl [5-(benzoylamino)-2-hydroxy-6-oxo-2-(trifluoromethyl)-3,6-dihydropyridin-1(2H)-yl]acetate

Chemical Property of methyl [5-(benzoylamino)-2-hydroxy-6-oxo-2-(trifluoromethyl)-3,6-dihydropyridin-1(2H)-yl]acetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl [5-(benzoylamino)-2-hydroxy-6-oxo-2-(trifluoromethyl)-3,6-dihydropyridin-1(2H)-yl]acetate

There total 1 articles about methyl [5-(benzoylamino)-2-hydroxy-6-oxo-2-(trifluoromethyl)-3,6-dihydropyridin-1(2H)-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

2-oxo-6-trifluoromethyl-2H-pyran-3-yl-N-benzamide (312615-59-1) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → methyl [5-(benzoylamino)-2-hydroxy-6-oxo-2-(trifluoromethyl)-3,6-dihydropyridin-1(2H)-yl]acetate (1305340-10-6)

Guidance literature:

glycine ethyl ester hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-oxo-6-trifluoromethyl-2H-pyran-3-yl-N-benzamide; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 6h;

DOI:10.1055/s-0030-1258448

Reference yield: 81.0%

methyl [5-(benzoylamino)-2-hydroxy-6-oxo-2-(trifluoromethyl)-3,6-dihydropyridin-1(2H)-yl]acetate (1305340-10-6) → C16H17F3N2O5

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; In tetrahydrofuran; at 25 ℃; for 8h; under 30402 Torr; Autoclave;

DOI:10.1055/s-0030-1258448

Reference yield: 61.0%

methyl [5-(benzoylamino)-2-hydroxy-6-oxo-2-(trifluoromethyl)-3,6-dihydropyridin-1(2H)-yl]acetate (1305340-10-6) → methyl [3-(benzoylamino)-2-oxo-6-(trifluoromethyl)pyridin-1(2H)-yl]acetate (1305340-16-2) + N-[2,5-dioxo-8a-(trifluoromethyl)-2,3,8,8a-tetrahydro-5H-[1,3]oxazolo[3,2-a]pyridin-6-yl]benzamide

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Reflux;

DOI:10.1055/s-0030-1258448

upstream raw materials:

2-oxo-6-trifluoromethyl-2H-pyran-3-yl-N-benzamide

glycine ethyl ester hydrochloride

Downstream raw materials:

methyl [3-(benzoylamino)-2-oxo-6-(trifluoromethyl)pyridin-1(2H)-yl]acetate