5-Ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid

Base Information

• Chemical Name: 5-Ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid
• CAS No.: 101184-10-5
• Molecular Formula: C6H8 N2 O3
• Molecular Weight: 156.14
• DSSTox Substance ID: DTXSID50550409
• Mol file: 101184-10-5.mol

Synonyms:101184-10-5;5-ETHYL-2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID;5-ETHYL-2-OXO-1,3-DIHYDROIMIDAZOLE-4-CARBOXYLIC ACID;1H-Imidazole-4-carboxylicacid,5-ethyl-2,3-dihydro-2-oxo-(9CI);5-Ethyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxylic acid;BIIBLAGNYXUUEI-UHFFFAOYSA-N;SCHEMBL7341880;DTXSID50550409;2,3-dihydro-5-ethyl-2-oxo-1H-imidazole-4-carboxylic acid

Chemical Property of 5-Ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid

Chemical Property:

• PKA: 6.92±0.20(Predicted)
• PSA: 86.21000
• Density: 1.341±0.06 g/cm3(Predicted)
• LogP: 0.37590
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 156.05349212
• Heavy Atom Count: 11
• Complexity: 244

Purity/Quality:

98%min ^*data from raw suppliers

5-ethyl-2,3-dihydro-2-oxo-1H-Imidazole-4-carboxylicacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(NC(=O)N1)C(=O)O

Technology Process of 5-Ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid

There total 4 articles about 5-Ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid methyl ester (119924-88-8) → 5-ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid (101184-10-5)

Guidance literature:

With sodium hydroxide; at 60 - 65 ℃; for 2h;

DOI:10.1021/jm00126a005

Reference yield:

methyl propanoyl acetate (30414-53-0) → 5-ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid (101184-10-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / NaNO₂, glacial acetic acid / H₂O / 2 h / 15 °C

2: H₂, 1.5 M HCl / Pd / ethanol / 4 h / 2585.7 Torr

3: 5 M HCl / H₂O / 18 h / Ambient temperature

4: 92 percent / 3 M NaOH / 2 h / 60 - 65 °C

With hydrogenchloride; sodium hydroxide; hydrogen; acetic acid; sodium nitrite; palladium; In ethanol; water;

DOI:10.1021/jm00126a005

Reference yield:

methyl 2‐(hydroxyimino)‐3‐oxopentanoate (119924-96-8,289882-13-9) → 5-ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid (101184-10-5)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂, 1.5 M HCl / Pd / ethanol / 4 h / 2585.7 Torr

2: 5 M HCl / H₂O / 18 h / Ambient temperature

3: 92 percent / 3 M NaOH / 2 h / 60 - 65 °C

With hydrogenchloride; sodium hydroxide; hydrogen; palladium; In ethanol; water;

DOI:10.1021/jm00126a005

upstream raw materials:

5-ethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid methyl ester

methyl propanoyl acetate

methyl 2‐(hydroxyimino)‐3‐oxopentanoate

Downstream raw materials:

4-ethyl-1,3-dihydro-5-[4-(1H-imidazol-2-yl)benzoyl]-2H-imidazol-2-one

4-ethyl-1,3-dihydro-5-<4-(1H-imidazol-1-ylmethyl)benzoyl>-2H-imidazol-2-one

4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)benzoyl]-2H-imidazol-2-one

4-benzoyl-5-ethyl-1,3-dihydro-2H-imidazol-2-one