3',5'-di-O-(tert-butyldiphenyl)silyl-2'-deoxy-5-formyluridine

Base Information

• Chemical Name: 3',5'-di-O-(tert-butyldiphenyl)silyl-2'-deoxy-5-formyluridine
• CAS No.: 118068-37-4
• Molecular Formula: C₄₂H₄₈N₂O₆Si₂
• Molecular Weight: 733.024
• Mol file: 118068-37-4.mol

Synonyms:3',5'-di-O-(tert-butyldiphenyl)silyl-2'-deoxy-5-formyluridine

Chemical Property of 3',5'-di-O-(tert-butyldiphenyl)silyl-2'-deoxy-5-formyluridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3',5'-di-O-(tert-butyldiphenyl)silyl-2'-deoxy-5-formyluridine

There total 5 articles about 3',5'-di-O-(tert-butyldiphenyl)silyl-2'-deoxy-5-formyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3',5'-di-O-(tert-butyldiphenyl)silyl-α-hydroxythymidine (118068-36-3) → 3',5'-di-O-(tert-butyldiphenyl)silyl-2'-deoxy-5-formyluridine (118068-37-4)

Guidance literature:

With manganese(IV) oxide; In toluene; for 5h; Heating;

DOI:10.1248/cpb.36.1554

Reference yield:

3',5'-bis-O-(tert-butyldiphenylsilyl)-5-bromomethyl-2'-deoxyuridine (118070-22-7) → 3',5'-di-O-(tert-butyldiphenyl)silyl-2'-deoxy-5-formyluridine (118068-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / H₂O; tetrahydrofuran / Ambient temperature

2: 73 percent / MnO₂ / toluene / 5 h / Heating

With manganese(IV) oxide; sodium hydrogencarbonate; In tetrahydrofuran; water; toluene;

DOI:10.1248/cpb.36.1554

Reference yield:

3',5'-bis-O-(tert-butyldiphenylsilyl)-thymidine (118068-35-2) → 3',5'-di-O-(tert-butyldiphenyl)silyl-2'-deoxy-5-formyluridine (118068-37-4)

Guidance literature:

Multi-step reaction with 3 steps

1: N-bromosuccinimide / CCl₄ / 2 h / Heating; Irradiation

2: NaHCO₃ / H₂O; tetrahydrofuran / Ambient temperature

3: 73 percent / MnO₂ / toluene / 5 h / Heating

With manganese(IV) oxide; N-Bromosuccinimide; sodium hydrogencarbonate; In tetrahydrofuran; tetrachloromethane; water; toluene;

DOI:10.1248/cpb.36.1554

upstream raw materials:

3',5'-di-O-(tert-butyldiphenyl)silyl-α-hydroxythymidine

3',5'-bis-O-(tert-butyldiphenylsilyl)-thymidine

3',5'-bis-O-(tert-butyldiphenylsilyl)-5-bromomethyl-2'-deoxyuridine

tert-butylchlorodiphenylsilane

Downstream raw materials:

α,α-difluorothymidine

3',5'-di-O-(tert-butyldiphenyl)silyl-α,α-difluorothymidine