(2R,5S)-7-Oxo-1-azabicyclo[3.2.0]hept-3-ene-2-carboxylic acid (4-nitrophenyl)methyl ester

Base Information

Chemical Name:(2R,5S)-7-Oxo-1-azabicyclo[3.2.0]hept-3-ene-2-carboxylic acid (4-nitrophenyl)methyl ester
CAS No.:77998-55-1
Molecular Formula:C₁₄H₁₂N₂O₅
Molecular Weight:288.26
Hs Code.:
Mol file:77998-55-1.mol

Synonyms:p-nitrobenzyl 1-carbapen-1-em-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5S)-7-Oxo-1-azabicyclo[3.2.0]hept-3-ene-2-carboxylic acid (4-nitrophenyl)methyl ester

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Technology Process of (2R,5S)-7-Oxo-1-azabicyclo[3.2.0]hept-3-ene-2-carboxylic acid (4-nitrophenyl)methyl ester

There total 2 articles about (2R,5S)-7-Oxo-1-azabicyclo[3.2.0]hept-3-ene-2-carboxylic acid (4-nitrophenyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 77998-54-0
sodium 1-carbaphen

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 77998-55-1
p-nitrobenzyl 1-carbapen-1-em-3-carboxylate

Guidance literature:: In dimethyl sulfoxide; for 1h; Ambient temperature;
DOI:10.1021/ja00405a039

Reference yield:

: 68485-99-4
methyl 1-carbapen-2-em-3-carboxylate

: 77998-55-1
p-nitrobenzyl 1-carbapen-1-em-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 37 percent / DBU / tetrahydrofuran / 24 h / Ambient temperature

2: 100 percent / aq. NaOH / acetonitrile / 0.5 h / 0 °C

3: 63 percent / dimethylsulfoxide / 1 h / Ambient temperature

With sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/ja00405a039