N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-4-methylthiophene-2-carboximidamide

Base Information

• Chemical Name: N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-4-methylthiophene-2-carboximidamide
• CAS No.: 1569735-64-3
• Molecular Formula: C₁₉H₂₄N₂OS₂
• Molecular Weight: 360.544
• Mol file: 1569735-64-3.mol

Synonyms:N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-4-methylthiophene-2-carboximidamide

Chemical Property of N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-4-methylthiophene-2-carboximidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-4-methylthiophene-2-carboximidamide

There total 5 articles about N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-4-methylthiophene-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

4-methylthiophene-2-carbonitrile (73305-93-8) + 3-[(cyclopentylsulfanyl)methyl]-4-methoxyaniline (1343811-07-3) → N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-4-methylthiophene-2-carboximidamide (1569735-64-3)

Guidance literature:

With aluminum (III) chloride; In 1,2-dichloro-ethane; at 115 ℃;

DOI:10.1021/ml400519h

Reference yield:

para-methoxynitrobenzene (100-17-4) → N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-4-methylthiophene-2-carboximidamide (1569735-64-3)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid; sodium bromide; acetic acid / 3 h / 85 °C

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

3: acetic acid; iron / 7 h / 30 - 60 °C / Inert atmosphere

4: aluminum (III) chloride / 1,2-dichloro-ethane / 115 °C

With aluminum (III) chloride; sulfuric acid; iron; potassium carbonate; acetic acid; sodium bromide; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/ml400519h

Reference yield:

2-[(cyclopentylsulfanyl)methyl]-1-methoxy-4-nitrobenzene (1569735-46-1) → N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-4-methylthiophene-2-carboximidamide (1569735-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; iron / 7 h / 30 - 60 °C / Inert atmosphere

2: aluminum (III) chloride / 1,2-dichloro-ethane / 115 °C

With aluminum (III) chloride; iron; acetic acid; In 1,2-dichloro-ethane;

DOI:10.1021/ml400519h

upstream raw materials:

para-methoxynitrobenzene

2-[(cyclopentylsulfanyl)methyl]-1-methoxy-4-nitrobenzene

2-methoxy-5-nitrobenzyl bromide

4-methylthiophene-2-carbonitrile