5-chloro-2-methoxy-N-[1-(2-methoxy-ethyl)-4-methyl-[1,4]diazepan-6-yl]-4-methylamino-benzamide

Base Information

Chemical Name:5-chloro-2-methoxy-N-[1-(2-methoxy-ethyl)-4-methyl-[1,4]diazepan-6-yl]-4-methylamino-benzamide
CAS No.:483304-33-2
Molecular Formula:C₁₈H₂₉ClN₄O₃
Molecular Weight:384.906
Hs Code.:

5-chloro-2-methoxy-<i>N</i>-[1-(2-methoxy-ethyl)-4-methyl-[1,4]diazepan-6-yl]-4-methylamino-benzamide

Synonyms:5-chloro-2-methoxy-N-[1-(2-methoxy-ethyl)-4-methyl-[1,4]diazepan-6-yl]-4-methylamino-benzamide

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Chemical Property of 5-chloro-2-methoxy-N-[1-(2-methoxy-ethyl)-4-methyl-[1,4]diazepan-6-yl]-4-methylamino-benzamide

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Technology Process of 5-chloro-2-methoxy-N-[1-(2-methoxy-ethyl)-4-methyl-[1,4]diazepan-6-yl]-4-methylamino-benzamide

There total 7 articles about 5-chloro-2-methoxy-N-[1-(2-methoxy-ethyl)-4-methyl-[1,4]diazepan-6-yl]-4-methylamino-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146759-95-7
N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepine-6-yl)benzamide

: 483304-33-2
5-chloro-2-methoxy-N-[1-(2-methoxy-ethyl)-4-methyl-[1,4]diazepan-6-yl]-4-methylamino-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / H₂ / 10 percent Pd/C / ethanol; acetic acid / 50 °C / atmospheric pressure

2: 60 percent / NaBH₄ / toluene / 3 h / Heating

3: 100 percent / 35 percent aq. HCl / 8 h / Heating

4: EDC / CH₂Cl₂ / 20 °C

With hydrogenchloride; sodium tetrahydroborate; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; toluene;
DOI:10.1248/cpb.50.941

Reference yield:

: 61694-98-2
5-chloro-2-methoxy-4-(methylamino)benzoic acid

: 483303-82-8
6-amino-1-(2-methoxyethyl)-4-methylhexahydro-1,4-diazepine

: 483304-33-2
5-chloro-2-methoxy-N-[1-(2-methoxy-ethyl)-4-methyl-[1,4]diazepan-6-yl]-4-methylamino-benzamide

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1248/cpb.50.941

Reference yield:

: 78775-31-2
4-(p-toluenesulfonyl)aminosalicylic acid

: 483304-33-2
5-chloro-2-methoxy-N-[1-(2-methoxy-ethyl)-4-methyl-[1,4]diazepan-6-yl]-4-methylamino-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / KOH / acetone / 2 h / Heating

2: NCS / dimethylformamide / 80 °C

3: conc. H₂SO₄ / 1.5 h

4: EDC / CH₂Cl₂ / 20 °C

With potassium hydroxide; N-chloro-succinimide; sulfuric acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.50.941