(S)-(+)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate

Base Information

Chemical Name:(S)-(+)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate
CAS No.:81381-92-2
Molecular Formula:C₂₇H₃₄N₄O₃
Molecular Weight:462.592
Hs Code.:

Synonyms:(S)-(+)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate

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Chemical Property of (S)-(+)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate

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Technology Process of (S)-(+)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate

There total 24 articles about (S)-(+)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1144-74-7
4-nitrobenzophenone

: 81381-92-2
(RS)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>phenyl>-α-phenylacetate

Guidance literature:: Multi-step reaction with 7 steps

1: ZnI₂ / CH₂Cl₂ / 72 h / Ambient temperature

2: 3 N aq. HCl / 24 h / Ambient temperature

3: 1.) K₂CO₃, dicyclohexano-18-crown-6 / 1.) acetonitrile, RT, 0.5 h, 2.) acetonitrile, RT, 96 h

4: 100 percent / H₂ / Pd-polyethylamine / methanol / 24 h / 2280 Torr

5: 1.) Na / 1.) benzene, reflux, 0.5 h, 2.) benzene, reflux, 24 h

6: 10percent aq. H₂SO₄, sodium nitrite / acetone; H₂O / 0.25 h / 0 °C

7: H₂O / 0.33 h / 0 °C

With hydrogenchloride; perhydrodibenzo-18-crown-6; sulfuric acid; hydrogen; sodium; potassium carbonate; zinc(II) iodide; sodium nitrite; Pd-polyethylamine; In methanol; dichloromethane; water; acetone;
DOI:10.1021/jm00368a009

Reference yield:

: 1144-74-7
4-nitrobenzophenone

: 81381-92-2
(S)-(+)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate

Guidance literature:: Multi-step reaction with 6 steps

1: ZnI₂ / CH₂Cl₂ / 72 h / Ambient temperature

2: 3 N aq. HCl / 24 h / Ambient temperature

3: 1.) K₂CO₃, dicyclohexano-18-crown-6 / 1.) acetonitrile, RT, 0.5 h, 2.) acetonitrile, RT, 96 h

4: 100 percent / H₂ / Pd-polyethylamine / methanol / 24 h / 2280 Torr

5: 1.) Na / 1.) benzene, reflux, 0.5 h, 2.) benzene, reflux, 24 h

6: 1.) 10percent aq. H₂SO₄, sodium nitrite / 1.) acetone, water, 0 deg C, 15 min, 2.) water, 0 deg C, 20 min

With hydrogenchloride; perhydrodibenzo-18-crown-6; sulfuric acid; hydrogen; sodium; potassium carbonate; zinc(II) iodide; sodium nitrite; Pd-polyethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00368a009

Reference yield:

: 1144-74-7
4-nitrobenzophenone

: 81381-92-2
(R)-(-)-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate

Guidance literature:: Multi-step reaction with 6 steps

1: ZnI₂ / CH₂Cl₂ / 72 h / Ambient temperature

2: 3 N aq. HCl / 24 h / Ambient temperature

3: 1.) K₂CO₃, dicyclohexano-18-crown-6 / 1.) acetonitrile, RT, 0.5 h, 2.) acetonitrile, RT, 96 h

4: 100 percent / H₂ / Pd-polyethylamine / methanol / 24 h / 2280 Torr

5: 1.) Na / 1.) benzene, reflux, 0.5 h, 2.) benzene, reflux, 24 h

6: 1.) 10percent aq. H₂SO₄, sodium nitrite / 1.) acetone, water, 0 deg C, 15 min, 2.) water, 0 deg C, 20 min

With hydrogenchloride; perhydrodibenzo-18-crown-6; sulfuric acid; hydrogen; sodium; potassium carbonate; zinc(II) iodide; sodium nitrite; Pd-polyethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00368a009