(6-amino-4-decyloxy-pyridin-2-yl)carbamic acid benzyl ester

Base Information

• Chemical Name: (6-amino-4-decyloxy-pyridin-2-yl)carbamic acid benzyl ester
• CAS No.: 796885-05-7
• Molecular Formula: C₂₃H₃₃N₃O₃
• Molecular Weight: 399.533
• Mol file: 796885-05-7.mol

Synonyms:(6-amino-4-decyloxy-pyridin-2-yl)carbamic acid benzyl ester

Chemical Property of (6-amino-4-decyloxy-pyridin-2-yl)carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (6-amino-4-decyloxy-pyridin-2-yl)carbamic acid benzyl ester

There total 1 articles about (6-amino-4-decyloxy-pyridin-2-yl)carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

benzyl chloroformate (501-53-1,94274-21-2) + 4-decyloxy-2,6-diaminopyridine (362620-01-7) → (6-amino-4-decyloxy-pyridin-2-yl)carbamic acid benzyl ester (796885-05-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 17h;

DOI:10.1016/j.tet.2004.07.078

Reference yield:

(6-amino-4-decyloxy-pyridin-2-yl)carbamic acid benzyl ester (796885-05-7) → 6-(6-{[6-(6-benzyloxycarbonylamino-4-decyloxy-pyridin-2-ylcarbamoyl)-4-decyloxy-pyridine-2-carbonyl]-amino}-4-decyloxy-pyridin-2-ylcarbamoyl)-4-decyloxy-pyridine-2-carboxylic acid (796885-19-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 2.63 g / N,N-diisopropylethylamine / toluene / 0 - 20 °C

2: 100 percent / H₂ / Pd/C / dimethylformamide; methanol / 20 °C / atmospheric pressure

3: 1.78 g / N,N-diisopropylethylamine / toluene / 0 - 20 °C

4: 100 percent / aq. NaOH / dioxane / 2 h / 20 °C

With sodium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.tet.2004.07.078

Reference yield:

(6-amino-4-decyloxy-pyridin-2-yl)carbamic acid benzyl ester (796885-05-7) → 6-(6-{[6-(6-benzyloxycarbonylamino-4-decyloxy-pyridin-2-ylcarbamoyl)-4-decyloxy-pyridine-2-carbonyl]-amino}-4-decyloxy-pyridin-2-ylcarbamoyl)-4-decyloxy-pyridine-2-carboxylic acid methyl ester (796885-15-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.63 g / N,N-diisopropylethylamine / toluene / 0 - 20 °C

2: 100 percent / H₂ / Pd/C / dimethylformamide; methanol / 20 °C / atmospheric pressure

3: 1.78 g / N,N-diisopropylethylamine / toluene / 0 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.tet.2004.07.078

upstream raw materials:

benzyl chloroformate

4-decyloxy-2,6-diaminopyridine

Downstream raw materials:

6-(6-benzyloxycarbonylamino-4-decyloxy-pyridin-2-ylcarbamoyl)-4-decyloxy-pyridine-2-carboxylic acid methyl ester

6-(6-benzyloxycarbonylamino-4-decyloxy-pyridin-2-ylcarbamoyl)-4-decyloxy-pyridine-2-carboxylic acid

6-(6-{[6-(6-benzyloxycarbonylamino-4-decyloxy-pyridin-2-ylcarbamoyl)-4-decyloxy-pyridine-2-carbonyl]-amino}-4-decyloxy-pyridin-2-ylcarbamoyl)-4-decyloxy-pyridine-2-carboxylic acid

6-(6-{[6-(6-benzyloxycarbonylamino-4-decyloxy-pyridin-2-ylcarbamoyl)-4-decyloxy-pyridine-2-carbonyl]-amino}-4-decyloxy-pyridin-2-ylcarbamoyl)-4-decyloxy-pyridine-2-carboxylic acid methyl ester