methyl (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tertbutoxyphenyl)propanoate

Base Information

• Chemical Name: methyl (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tertbutoxyphenyl)propanoate
• CAS No.: 1190366-67-6
• Molecular Formula: C₂₇H₃₇NO₄
• Molecular Weight: 439.595
• Mol file: 1190366-67-6.mol

Synonyms:methyl (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tertbutoxyphenyl)propanoate

Chemical Property of methyl (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tertbutoxyphenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tertbutoxyphenyl)propanoate

There total 2 articles about methyl (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tertbutoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-ibuprofen (51146-56-6,58560-75-1) + O-tert-butyl-L-tyrosine methyl ester hydrochloride → methyl (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tertbutoxyphenyl)propanoate (1190366-67-6)

Guidance literature:

(S)-ibuprofen; With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

O-tert-butyl-L-tyrosine methyl ester hydrochloride; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1055/s-0033-1341068

Reference yield: 95.0%

O-tert-butyl-L-tyrosine methyl ester (52616-82-7) + (S)-ibuprofen (51146-56-6,58560-75-1) → methyl (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tertbutoxyphenyl)propanoate (1190366-67-6)

Guidance literature:

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1021/mp2003016

Reference yield: 98.0%

methyl (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tertbutoxyphenyl)propanoate (1190366-67-6) → (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tert-butoxyphenyl)propanoic acid (1190366-68-7)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 1h;

DOI:10.1055/s-0033-1341068

upstream raw materials:

O-tert-butyl-L-tyrosine methyl ester

(S)-ibuprofen

Downstream raw materials:

C₂₈H₃₉N₅O₅

C₂₈H₄₀N₆O₄

(S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tert-butoxyphenyl)propanoic acid

C₃₃H₄₉N₅O₅