3-(2-ethoxyphenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-5-methylquinazolin-4(3H)-one

Base Information

Chemical Name:3-(2-ethoxyphenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-5-methylquinazolin-4(3H)-one
CAS No.:1333248-15-9
Molecular Formula:C₂₇H₂₈N₄O₄
Molecular Weight:472.544
Hs Code.:

Synonyms:3-(2-ethoxyphenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-5-methylquinazolin-4(3H)-one

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Chemical Property of 3-(2-ethoxyphenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-5-methylquinazolin-4(3H)-one

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Technology Process of 3-(2-ethoxyphenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-5-methylquinazolin-4(3H)-one

There total 3 articles about 3-(2-ethoxyphenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-5-methylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₇ClN₂O₂

: 40172-95-0
N-(furan-2-carbonyl)piperazine

: 1333248-15-9
3-(2-ethoxyphenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-5-methylquinazolin-4(3H)-one

Guidance literature:: C₁₈H₁₇ClN₂O₂; With potassium carbonate; In ethanol; acetonitrile; at 150 ℃; for 0.0833333h; Microwave irradiation;

N-(furan-2-carbonyl)piperazine; In ethanol; acetonitrile; at 150 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1016/j.bmcl.2011.07.043

Reference yield:

: 4389-50-8
2-amino-6-methylbenzoic acid

: 1333248-15-9
3-(2-ethoxyphenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-5-methylquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 - 20 °C

2.1: trichlorophosphate / acetonitrile / 0.25 h / 150 °C / Microwave irradiation

3.1: potassium carbonate / ethanol; acetonitrile / 0.08 h / 150 °C / Microwave irradiation

3.2: 0.17 h / 150 °C / Microwave irradiation

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2011.07.043

Reference yield:

: 66232-40-4
2-[(chloroacetyl)amino]-6-methylbenzoic acid

: 1333248-15-9
3-(2-ethoxyphenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-5-methylquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / acetonitrile / 0.25 h / 150 °C / Microwave irradiation

2.1: potassium carbonate / ethanol; acetonitrile / 0.08 h / 150 °C / Microwave irradiation

2.2: 0.17 h / 150 °C / Microwave irradiation

With potassium carbonate; trichlorophosphate; In ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2011.07.043