(4S,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylpyrrolidin-2-one

Base Information

Chemical Name:(4S,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylpyrrolidin-2-one
CAS No.:138871-60-0
Molecular Formula:C₂₇H₃₇NO₄Si
Molecular Weight:467.681
Hs Code.:

Synonyms:(4S,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylpyrrolidin-2-one

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Chemical Property of (4S,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylpyrrolidin-2-one

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Technology Process of (4S,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylpyrrolidin-2-one

There total 4 articles about (4S,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 15681-48-8
lithium dimethylcuprate

: 138871-58-6
(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 138871-60-0
(4S,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylpyrrolidin-2-one

Guidance literature:: In diethyl ether; at -78 ℃;
DOI:10.1016/0040-4039(91)80452-C

Reference yield: 62.0%

: 917-54-4
methyllithium

: 138871-58-6
(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 138871-60-0
(4S,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylpyrrolidin-2-one

Guidance literature:: methyllithium; With copper(l) iodide; In diethyl ether; toluene; at -78 - -40 ℃; for 1h;

(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester; In diethyl ether; toluene; at -78 - -40 ℃;
DOI:10.1021/ja062960c

Reference yield:

: 138629-30-8,138871-56-4
(S)-tert-butyl 2-((tert-butyldiphenylsilyloxy)methyl)-5-oxopyrrolidine-1-carboxylate

: 138871-60-0
(4S,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / -78 - 0 °C

1.2: 60 percent / tetrahydrofuran / -78 - 20 °C

2.1: 86 percent / aq. H₂O₂ / tetrahydrofuran; acetic acid / 0.5 h / 0 °C

3.1: CuI / diethyl ether; toluene / 1 h / -78 - -40 °C

3.2: 62 percent / diethyl ether; toluene / -78 - -40 °C

With copper(l) iodide; dihydrogen peroxide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; acetic acid; toluene;
DOI:10.1021/ja062960c