methyl 5-bromo-2-fluoro-4-(tetrahydro-2H-pyran-2-yloxy)benzoate

Base Information

• Chemical Name: methyl 5-bromo-2-fluoro-4-(tetrahydro-2H-pyran-2-yloxy)benzoate
• CAS No.: 1142227-36-8
• Molecular Formula: C₁₃H₁₄BrFO₄
• Molecular Weight: 333.154
• Mol file: 1142227-36-8.mol

Synonyms:methyl 5-bromo-2-fluoro-4-(tetrahydro-2H-pyran-2-yloxy)benzoate

Chemical Property of methyl 5-bromo-2-fluoro-4-(tetrahydro-2H-pyran-2-yloxy)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-bromo-2-fluoro-4-(tetrahydro-2H-pyran-2-yloxy)benzoate

There total 3 articles about methyl 5-bromo-2-fluoro-4-(tetrahydro-2H-pyran-2-yloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3,4-dihydro-2H-pyran (110-87-2) + 5-bromo-2-fluoro-4-hydroxybenzoic acid methyl ester (1142227-35-7) → methyl 5-bromo-2-fluoro-4-(tetrahydro-2H-pyran-2-yloxy)benzoate (1142227-36-8)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 50 ℃; for 24h;

Reference yield:

methyl 2-fluoro-4-hydroxybenzoate (197507-22-5) → methyl 5-bromo-2-fluoro-4-(tetrahydro-2H-pyran-2-yloxy)benzoate (1142227-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; acetic acid / tetrachloromethane; dichloromethane / 18 h / 45 °C

2: pyridinium p-toluenesulfonate / dichloromethane / 24 h / 50 °C

With bromine; pyridinium p-toluenesulfonate; acetic acid; In tetrachloromethane; dichloromethane;

Reference yield:

2-fluoro-4-hydroxybenzoic acid (65145-13-3) → methyl 5-bromo-2-fluoro-4-(tetrahydro-2H-pyran-2-yloxy)benzoate (1142227-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 20.5 h / 80 °C

2: bromine; acetic acid / tetrachloromethane; dichloromethane / 18 h / 45 °C

3: pyridinium p-toluenesulfonate / dichloromethane / 24 h / 50 °C

With sulfuric acid; bromine; pyridinium p-toluenesulfonate; acetic acid; In tetrachloromethane; dichloromethane;

upstream raw materials:

3,4-dihydro-2H-pyran

5-bromo-2-fluoro-4-hydroxybenzoic acid methyl ester

methyl 2-fluoro-4-hydroxybenzoate

2-fluoro-4-hydroxybenzoic acid

Downstream raw materials:

methyl 5-(5,5-dimethylcyclopent-1-enyl)-2-fluoro-4-(tetrahydro-2H-pyran-2-yloxy)benzoate

methyl 2-(5,5-dimethyl-1-cyclopenten-1-yl)-2',5-difluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

methyl 5-(5,5-dimethylcyclopent-1-enyl)-2-fluoro-4-(trifluoromethylsulfonyloxy)benzoate

methyl 5-(5,5-dimethylcyclopent-1-enyI)-2-fluoro-4-hydroxybenzoate