N-(2-(6-(hydroxyamino)-6-oxohexyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-4-iodobenzamide

Base Information

Chemical Name:N-(2-(6-(hydroxyamino)-6-oxohexyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-4-iodobenzamide
CAS No.:1569314-88-0
Molecular Formula:C₂₀H₂₀IN₃O₆S
Molecular Weight:557.366
Hs Code.:

Synonyms:N-(2-(6-(hydroxyamino)-6-oxohexyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-4-iodobenzamide

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Chemical Property of N-(2-(6-(hydroxyamino)-6-oxohexyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-4-iodobenzamide

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Technology Process of N-(2-(6-(hydroxyamino)-6-oxohexyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-4-iodobenzamide

There total 6 articles about N-(2-(6-(hydroxyamino)-6-oxohexyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-4-iodobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1569314-62-0
6-(6-(4-iodobenzamido)-1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)hexanoic acid

: 1569314-88-0
N-(2-(6-(hydroxyamino)-6-oxohexyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-4-iodobenzamide

Guidance literature:: 6-(6-(4-iodobenzamido)-1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)hexanoic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With hydroxylamine hydrochloride; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/j.bmc.2014.01.045

Reference yield:

: 22952-24-5
6-nitrosaccharin

: 1569314-88-0
N-(2-(6-(hydroxyamino)-6-oxohexyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-4-iodobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 60 - 80 °C

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 4 h / 20 °C / 760.05 Torr

3.1: sodium hydrogencarbonate / tetrahydrofuran / 8 h / 20 °C

4.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / 0 °C

4.2: 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.01.045

Reference yield:

: 619-58-9
4-iodobenzoic acid

: 1569314-88-0
N-(2-(6-(hydroxyamino)-6-oxohexyl)-1,1-dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yl)-4-iodobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 2 h / 60 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran / 8 h / 20 °C

3.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / 0 °C

3.2: 20 °C

With thionyl chloride; sodium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; isobutyl chloroformate; In tetrahydrofuran;
DOI:10.1016/j.bmc.2014.01.045