1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrazole-3-carboxylic acid amide

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Chemical Name:1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrazole-3-carboxylic acid amide
CAS No.:1413062-71-1
Molecular Formula:C₂₃H₂₂FN₅O₃
Molecular Weight:435.458
Hs Code.:

Synonyms:1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrazole-3-carboxylic acid amide

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Chemical Property of 1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrazole-3-carboxylic acid amide

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Technology Process of 1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrazole-3-carboxylic acid amide

There total 4 articles about 1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrazole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1413065-61-8
1-(3-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-2-(hydroxymethyl)phenyl)-1H-pyrazole-3-carbonitrile

: 1413062-71-1
1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: With water; [hydrogen bis(dimethylphosphinito-kP)]platinum (II); In ethanol; at 80 ℃; for 2h;

Reference yield:

: 360575-28-6
2-bromo-6-fluorobenzaldehyde

: 1413062-71-1
1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.33 h / 20 °C

1.2: 20 °C

2.1: sodium hydrogencarbonate; copper(l) iodide / dimethyl sulfoxide / 1 h / 120 °C / Microwave irradiation

3.1: sodium tetrahydroborate; methanol / dichloromethane / 1 h

4.1: water / [hydrogen bis(dimethylphosphinito-kP)]platinum (II) / ethanol / 2 h / 80 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; potassium tert-butylate; water; sodium hydrogencarbonate; [hydrogen bis(dimethylphosphinito-kP)]platinum (II); In ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1413065-58-3
1-(3-bromo-2-formylphenyl)-1H-pyrazole-3-carbonitrile

: 1413062-71-1
1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; copper(l) iodide / dimethyl sulfoxide / 1 h / 120 °C / Microwave irradiation

2: sodium tetrahydroborate; methanol / dichloromethane / 1 h

3: water / [hydrogen bis(dimethylphosphinito-kP)]platinum (II) / ethanol / 2 h / 80 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; water; sodium hydrogencarbonate; [hydrogen bis(dimethylphosphinito-kP)]platinum (II); In ethanol; dichloromethane; dimethyl sulfoxide;