methyl 4,6-bis((tert-butyldimethylsilyl)oxy)-3-chloro-2-(3-oxopropyl)benzoate

Base Information

Chemical Name:methyl 4,6-bis((tert-butyldimethylsilyl)oxy)-3-chloro-2-(3-oxopropyl)benzoate
CAS No.:811788-13-3
Molecular Formula:C₂₃H₃₉ClO₅Si₂
Molecular Weight:487.184
Hs Code.:

Synonyms:methyl 4,6-bis((tert-butyldimethylsilyl)oxy)-3-chloro-2-(3-oxopropyl)benzoate

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Chemical Property of methyl 4,6-bis((tert-butyldimethylsilyl)oxy)-3-chloro-2-(3-oxopropyl)benzoate

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Technology Process of methyl 4,6-bis((tert-butyldimethylsilyl)oxy)-3-chloro-2-(3-oxopropyl)benzoate

There total 5 articles about methyl 4,6-bis((tert-butyldimethylsilyl)oxy)-3-chloro-2-(3-oxopropyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 811788-12-2
methyl 2-(but-3-enyl)-4,6-bis(tert-butyldimethylsilanyloxy)-3-chlorobenzoate

: 811788-13-3
methyl 4,6-bis((tert-butyldimethylsilyl)oxy)-3-chloro-2-(3-oxopropyl)benzoate

Guidance literature:: With sodium periodate; osmium(VIII) oxide; water; In 1,4-dioxane; for 8h;
DOI:10.1021/ol900783m

Reference yield:

: 811788-11-1
methyl 2,4-bis(tert-butyldimethylsilanyloxy)-3-chloro-6-methylbenzoate

: 811788-13-3
methyl 4,6-bis((tert-butyldimethylsilyl)oxy)-3-chloro-2-(3-oxopropyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / 0.08 h / -78 °C

1.2: 94 percent / tetrahydrofuran / -78 °C

2.1: O₃ / methanol; CH₂Cl₂ / 0.25 h / -78 °C

2.2: 83 percent / PPh₃ / methanol; CH₂Cl₂ / 25 h / 2 °C

With ozone; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol048266o

Reference yield:

: 811788-10-0
methyl 2,4-bis(tert-butyldimethylsilanyloxy)-6-methyl-benzoate

: 811788-13-3
methyl 4,6-bis((tert-butyldimethylsilyl)oxy)-3-chloro-2-(3-oxopropyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / Ca(OCl)2; AcOH / acetone; H₂O / 3.5 h / 25 °C

2.1: LDA / tetrahydrofuran / 0.08 h / -78 °C

2.2: 94 percent / tetrahydrofuran / -78 °C

3.1: O₃ / methanol; CH₂Cl₂ / 0.25 h / -78 °C

3.2: 83 percent / PPh₃ / methanol; CH₂Cl₂ / 25 h / 2 °C

With calcium hypochlorite; ozone; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; acetone;
DOI:10.1021/ol048266o