1,3-dimethyl-5-(3-oxo-1,3-diphenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione

Base Information

• Chemical Name: 1,3-dimethyl-5-(3-oxo-1,3-diphenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione
• CAS No.: 54890-67-4
• Molecular Formula: C₂₁H₂₀N₂O₄
• Molecular Weight: 364.401
• Mol file: 54890-67-4.mol

Synonyms:1,3-dimethyl-5-(3-oxo-1,3-diphenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione

Chemical Property of 1,3-dimethyl-5-(3-oxo-1,3-diphenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dimethyl-5-(3-oxo-1,3-diphenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione

There total 5 articles about 1,3-dimethyl-5-(3-oxo-1,3-diphenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,3-dimethylbarbituric acid (769-42-6) + benzalacetophenone (94-41-7) → 1,3-dimethyl-5-(3-oxo-1,3-diphenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione (54890-67-4)

Guidance literature:

With diethylamine; In dichloromethane; at 20 ℃; for 0.333333h; Solvent; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.10.108

Reference yield: 76.0%

1,3-dimethylbarbituric acid (769-42-6) + 1,3-diphenyl-propen-3-one (614-47-1) → 1,3-dimethyl-5-(3-oxo-1,3-diphenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione (54890-67-4)

Guidance literature:

With triethylamine; In methanol; at 80 - 85 ℃; for 4h;

DOI:10.1016/0040-4020(96)00537-6

Reference yield: 37.0%

1-(2-methyl-2,3-dihydrobenzothiazol-2-yl)-methyl phenyl ketone (50783-26-1) + 5-benzylidene-1,3-dimethyl-pyrimidine-2,4,6-trione (54459-73-3) → 1,3-dimethyl-5-(3-oxo-1,3-diphenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione (54890-67-4)

Guidance literature:

With Eosin Y; In 1,2-dichloro-ethane; at 20 ℃; for 24h; Irradiation;

DOI:10.1039/c9cc05336k

upstream raw materials:

1,3-dimethylbarbituric acid

1,3-diphenyl-propen-3-one

benzalacetophenone

1-(2-methyl-2,3-dihydrobenzothiazol-2-yl)-methyl phenyl ketone

Downstream raw materials:

1,3-Dimethyl-5,7-diphenyl-pyrido<2,3-d>pyrimidin-2,4-(1H,3H)-dion

1,3-dimethyl-5,7-diphenyl-1,5-dihydro-pyrano[2,3-d]pyrimidine-2,4-dione