Mps1-IN-5

Base Information

Chemical Name:Mps1-IN-5
CAS No.:1443763-60-7
Molecular Formula:C₂₉H₂₆FN₅O₄S
Molecular Weight:559.621
Hs Code.:
Mol file:1443763-60-7.mol

Synonyms:(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5,α]pyridin-6-yl)phenyl]propanamide

Suppliers and Price of Mps1-IN-5

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Empesertib >98%
100 mg
$ 500.00

DC Chemicals
Empesertib >98%
250 mg
$ 1000.00

Crysdot
Mps1-IN-5 98+%
100mg
$ 1470.00

Crysdot
Mps1-IN-5 98+%
50mg
$ 1050.00

Crysdot
Mps1-IN-5 98+%
10mg
$ 350.00

Crysdot
Mps1-IN-5 98+%
5mg
$ 245.00

ChemScene
Empesertib ≥98.0%
5mg
$ 420.00

ChemScene
Empesertib ≥98.0%
100mg
$ 2520.00

ChemScene
Empesertib ≥98.0%
50mg
$ 1800.00

ChemScene
Empesertib ≥98.0%
10mg
$ 600.00

Total 18 raw suppliers

Chemical Property of Mps1-IN-5

Chemical Property:

PKA:13.71±0.70(Predicted)
Density:1.36±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

Empesertib >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Mps1-IN-5

There total 22 articles about Mps1-IN-5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

: 1539264-88-4
6-chloro-N-[2-methoxy-4-(methylsulfonyl)phenyl][1,2,4]triazolo[1,5-α]pyridin-2-amine

: 1539264-92-0
(4-{[(2R)-2-(4-fluorophenyl)propanoyl]amino}phenyl)boronic acid

: 1443763-60-7
(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5,α]pyridin-6-yl)phenyl]propanamide

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; In propan-1-ol; water; for 6h; Reflux;

Reference yield: 58.4%

: 1539264-96-4
(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)boronic acid

: 1539264-97-5
(2R)-N-(4-bromophenyl)-2-(4-fluorophenyl)propanamide

: 1443763-60-7
(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5,α]pyridin-6-yl)phenyl]propanamide

Guidance literature:: With palladium diacetate; potassium carbonate; XPhos; In propan-1-ol; water; for 1.5h; Reflux;

Reference yield:

: 34837-84-8
4-fluorobenzeneacetic acid methyl ester

: 1443763-60-7
(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5,α]pyridin-6-yl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 1 h / -78 - 0 °C

2.1: potassium hydroxide; water / ethanol / 4 h / 0 °C

3.1: ethyl acetate / Reflux

4.1: sodium hydrogencarbonate; HATU / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With water; sodium hydrogencarbonate; HATU; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;