4-(1-{1-[1-(4-carboxy-thiazol-2-yl)-2-methyl-2,3-bis-triethylsilanyloxy-butylcarbamoyl]-2-hydroxy-ethylthiocarbamoyl}-2-phenylselanyl-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:4-(1-{1-[1-(4-carboxy-thiazol-2-yl)-2-methyl-2,3-bis-triethylsilanyloxy-butylcarbamoyl]-2-hydroxy-ethylthiocarbamoyl}-2-phenylselanyl-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester
CAS No.:710354-57-7
Molecular Formula:C₄₇H₈₁N₅O₁₀S₂SeSi₃
Molecular Weight:1103.54
Hs Code.:

4-(1-{1-[1-(4-carboxy-thiazol-2-yl)-2-methyl-2,3-bis-triethylsilanyloxy-butylcarbamoyl]-2-hydroxy-ethylthiocarbamoyl}-2-phenylselanyl-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester

Synonyms:4-(1-{1-[1-(4-carboxy-thiazol-2-yl)-2-methyl-2,3-bis-triethylsilanyloxy-butylcarbamoyl]-2-hydroxy-ethylthiocarbamoyl}-2-phenylselanyl-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of 4-(1-{1-[1-(4-carboxy-thiazol-2-yl)-2-methyl-2,3-bis-triethylsilanyloxy-butylcarbamoyl]-2-hydroxy-ethylthiocarbamoyl}-2-phenylselanyl-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of 4-(1-{1-[1-(4-carboxy-thiazol-2-yl)-2-methyl-2,3-bis-triethylsilanyloxy-butylcarbamoyl]-2-hydroxy-ethylthiocarbamoyl}-2-phenylselanyl-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester

There total 12 articles about 4-(1-{1-[1-(4-carboxy-thiazol-2-yl)-2-methyl-2,3-bis-triethylsilanyloxy-butylcarbamoyl]-2-hydroxy-ethylthiocarbamoyl}-2-phenylselanyl-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 710354-59-9
4-(1-{1-[1-(4-ethoxycarbonyl-thiazol-2-yl)-2-methyl-2,3-bis-triethylsilanyloxy-butylcarbamoyl]-2-hydroxy-ethylthiocarbamoyl}-2-phenylselanyl-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester

: 710354-57-7
4-(1-{1-[1-(4-carboxy-thiazol-2-yl)-2-methyl-2,3-bis-triethylsilanyloxy-butylcarbamoyl]-2-hydroxy-ethylthiocarbamoyl}-2-phenylselanyl-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; ethanol; at 20 ℃; for 5h;
DOI:10.1016/j.tetlet.2004.03.099

Reference yield:

: 645-96-5
Benzeneselenol

: 710354-57-7
4-(1-{1-[1-(4-carboxy-thiazol-2-yl)-2-methyl-2,3-bis-triethylsilanyloxy-butylcarbamoyl]-2-hydroxy-ethylthiocarbamoyl}-2-phenylselanyl-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 94 percent / dimethylformamide / 2 h / 80 °C

2.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium; chloride; N-methylmorpholine / methanol / 6 h / 20 °C

2.2: 82 percent / aq. NaOH / methanol; dioxane; H₂O / 1 h / 20 °C

3.1: 83 percent / 2-chloro-1,3-dimethylimidazolidium hexafluorophosphate; 1-hydroxy-7-azabenzotriazole; i-Pr₂NEt / CH₂Cl₂ / 0.5 h / 20 °C

4.1: 85 percent / diethylamminosulfur trifluoride / CH₂Cl₂ / 0.08 h / -78 °C

5.1: 90 percent / H₂S / methanol; triethylamine / 6 h / 20 °C

6.1: 100 percent / aq. NaOH / ethanol; dioxane / 5 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; diethylamino-sulfur trifluoride; 2-chloro-1,3-dimethylimidazolidium hexafluorophosphate; hydrogen sulfide; chloride; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; triethylamine; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2004.03.099

Reference yield:

: 80149-80-0
2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate

: 710354-57-7
4-(1-{1-[1-(4-carboxy-thiazol-2-yl)-2-methyl-2,3-bis-triethylsilanyloxy-butylcarbamoyl]-2-hydroxy-ethylthiocarbamoyl}-2-phenylselanyl-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dioxane; H₂O / 20 h / 20 °C

1.2: 100 percent / p-TsOH / acetone / 6 h / 20 °C

2.1: 66 percent / PyBop; i-Pr₂NEt / CH₂Cl₂ / 2.5 h / 20 °C

3.1: 94 percent / dimethylformamide / 2 h / 80 °C

4.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium; chloride; N-methylmorpholine / methanol / 6 h / 20 °C

4.2: 82 percent / aq. NaOH / methanol; dioxane; H₂O / 1 h / 20 °C

5.1: 83 percent / 2-chloro-1,3-dimethylimidazolidium hexafluorophosphate; 1-hydroxy-7-azabenzotriazole; i-Pr₂NEt / CH₂Cl₂ / 0.5 h / 20 °C

6.1: 85 percent / diethylamminosulfur trifluoride / CH₂Cl₂ / 0.08 h / -78 °C

7.1: 90 percent / H₂S / methanol; triethylamine / 6 h / 20 °C

8.1: 100 percent / aq. NaOH / ethanol; dioxane / 5 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; diethylamino-sulfur trifluoride; 2-chloro-1,3-dimethylimidazolidium hexafluorophosphate; hydrogen sulfide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; chloride; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; triethylamine; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2004.03.099