methyl N-[N-(tert-butoxycarbonyl)-1-benzyltryptophyl]-1-benzyltryptophanate

Base Information

Chemical Name:methyl N-[N-(tert-butoxycarbonyl)-1-benzyltryptophyl]-1-benzyltryptophanate
CAS No.:1256796-97-0
Molecular Formula:C₄₂H₄₄N₄O₅
Molecular Weight:684.835
Hs Code.:

Synonyms:methyl N-[N-(tert-butoxycarbonyl)-1-benzyltryptophyl]-1-benzyltryptophanate

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Chemical Property of methyl N-[N-(tert-butoxycarbonyl)-1-benzyltryptophyl]-1-benzyltryptophanate

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Technology Process of methyl N-[N-(tert-butoxycarbonyl)-1-benzyltryptophyl]-1-benzyltryptophanate

There total 7 articles about methyl N-[N-(tert-butoxycarbonyl)-1-benzyltryptophyl]-1-benzyltryptophanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 902-16-9
(S)-(-)-N'-benzyltryptophan methyl ester hydrochloride

: N¹-benzyl-N-(tert-butoxycarbonyl)-L-tryptophan

: 1256796-97-0
methyl N-[N-(tert-butoxycarbonyl)-1-benzyltryptophyl]-1-benzyltryptophanate

Guidance literature:: N¹-benzyl-N-(tert-butoxycarbonyl)-L-tryptophan; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 0.166667h;

(S)-(-)-N'-benzyltryptophan methyl ester hydrochloride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1139/V10-100

Reference yield:

: C₇H₁₆NO₂⁽¹⁺⁾*C₄₂H₄₄N₄O₅*Cl^(1-)

: 1256796-97-0
methyl N-[N-(tert-butoxycarbonyl)-1-benzyltryptophyl]-1-benzyltryptophanate

: 60-31-1,70623-44-8
acetylcholine chloride

Guidance literature:: In chloroform-d1; Equilibrium constant;
DOI:10.1139/V10-100

Reference yield:

: 100-44-7
benzyl chloride

: 1256796-97-0
methyl N-[N-(tert-butoxycarbonyl)-1-benzyltryptophyl]-1-benzyltryptophanate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia; sodium; ferric nitrate / diethyl ether / Cooling with acetone-dry ice; Cooling with ice

2.1: hydrogenchloride / methanol / 20 °C

3.1: sodium hydroxide / 1,4-dioxane; water / 18 h / 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 0 °C

4.2: 0 - 20 °C

With hydrogenchloride; ammonia; sodium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; ferric nitrate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water;
DOI:10.1139/V10-100