7-AMINO-4-CHLORO INDAZOLE

Base Information

• Chemical Name: 7-AMINO-4-CHLORO INDAZOLE
• CAS No.: 100959-52-2
• Molecular Formula: C₇H₆ClN₃
• Molecular Weight: 167.598
• Mol file: 100959-52-2.mol

Synonyms:1H-Indazole,7-amino-4-chloro- (6CI)

Chemical Property of 7-AMINO-4-CHLORO INDAZOLE

Chemical Property:

• Melting Point: 204 °C
• Boiling Point: 411.4±25.0 °C(Predicted)
• PKA: 13.72±0.40(Predicted)
• PSA: 54.70000
• Density: 1.533±0.06 g/cm3(Predicted)
• LogP: 2.37970
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-1H-indazol-7-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-AMINO-4-CHLORO INDAZOLE

There total 4 articles about 7-AMINO-4-CHLORO INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-chloro-7-nitro-1(2)H-indazole (316810-81-8) → 7-amino-4-chloroindazole (100959-52-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

Reference yield:

3-chloro-2-methyl-6-nitrobenzenamine (51123-59-2) → 7-amino-4-chloroindazole (100959-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / NaNO₂; AcOH

2: 92 percent / H₂ / Pd/C / ethanol

With hydrogen; acetic acid; sodium nitrite; palladium on activated charcoal; In ethanol; 1: Cyclization / 2: Catalytic hydrogenation;

Reference yield:

3-chloro-2-methylbenzenamine (87-60-5) → 7-amino-4-chloroindazole (100959-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 25 percent / HNO₃; Ac₂O

2: 64 percent / NaNO₂; AcOH

3: 92 percent / H₂ / Pd/C / ethanol

With hydrogen; nitric acid; acetic anhydride; acetic acid; sodium nitrite; palladium on activated charcoal; In ethanol; 1: Nitration / 2: Cyclization / 3: Catalytic hydrogenation;

upstream raw materials:

acetic acid-(3-chloro-2-methyl-6-nitro-anilide)

4-chloro-7-nitro-1⁽²⁾H-indazole

3-chloro-2-methyl-6-nitrobenzenamine

3-chloro-2-methylbenzenamine

Refernces