(3aS,4S,5R,6R,7R,7aS)-4-hydroxy-2,2-dimethyl-7-(4-methylphenylsulfonamido)-5-phenylcarbonyloxy-6-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole

Base Information

Chemical Name:(3aS,4S,5R,6R,7R,7aS)-4-hydroxy-2,2-dimethyl-7-(4-methylphenylsulfonamido)-5-phenylcarbonyloxy-6-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole
CAS No.:872221-73-3
Molecular Formula:C₂₈H₃₅NO₇SSi
Molecular Weight:557.74
Hs Code.:

(3aS,4S,5R,6R,7R,7aS)-4-hydroxy-2,2-dimethyl-7-(4-methylphenylsulfonamido)-5-phenylcarbonyloxy-6-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole

Synonyms:(3aS,4S,5R,6R,7R,7aS)-4-hydroxy-2,2-dimethyl-7-(4-methylphenylsulfonamido)-5-phenylcarbonyloxy-6-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole

Suppliers and Price of (3aS,4S,5R,6R,7R,7aS)-4-hydroxy-2,2-dimethyl-7-(4-methylphenylsulfonamido)-5-phenylcarbonyloxy-6-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3aS,4S,5R,6R,7R,7aS)-4-hydroxy-2,2-dimethyl-7-(4-methylphenylsulfonamido)-5-phenylcarbonyloxy-6-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aS,4S,5R,6R,7R,7aS)-4-hydroxy-2,2-dimethyl-7-(4-methylphenylsulfonamido)-5-phenylcarbonyloxy-6-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole

There total 10 articles about (3aS,4S,5R,6R,7R,7aS)-4-hydroxy-2,2-dimethyl-7-(4-methylphenylsulfonamido)-5-phenylcarbonyloxy-6-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 872221-72-2
(3aS,4R,5R,5aS,8aS,8bS)-N-(7,7-dimethyl-2,2-dioxo-4-(trimethylsilanylethynyl)hexahydro-1,3,6,8-tetraoxa-2λ⁶-thia-as-indacen-5-yl)-4-methylbenzenesulfonamide

: 1863-63-4,21292-26-2,28271-83-2,143502-10-7
ammonium benzoate

: (3aS,4R,7S,7aR)-7-hydroxy-2,2-dimethyl-4-(4-methylphenylsulfonamido)-5-(2-trimethylsilyl-1-ethynyl)-3a,4,7,7a-tetrahydro-1,3-benzodioxole

: 872221-73-3
(3aS,4S,5R,6R,7R,7aS)-4-hydroxy-2,2-dimethyl-7-(4-methylphenylsulfonamido)-5-phenylcarbonyloxy-6-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole

Guidance literature:: In N,N-dimethyl-formamide; at 70 ℃; for 2h;
DOI:10.1021/ol052372o

Reference yield:

: 160309-18-2
(1R,4R,5S,6R)-4,5-(isopropylidenedioxy)-7-(4'-methylphenylsulfonyl)-7-azabicyclo<4.1.0>hept-2-ene

: 872221-73-3
(3aS,4S,5R,6R,7R,7aS)-4-hydroxy-2,2-dimethyl-7-(4-methylphenylsulfonamido)-5-phenylcarbonyloxy-6-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / toluene / 0.17 h / 0 °C

1.2: AlCl₃ / toluene / 18 h / 0 - 20 °C

2.1: 46 percent / N-methylmorpholine-N-oxide; OsO₄ / CH₂Cl₂ / 3 h / 20 °C

3.1: 82 percent / triethylamine; SO₂Cl₂ / CH₂Cl₂ / 0 - 20 °C

4.1: dimethylformamide / 2 h / 70 °C

4.2: 33 percent / H₂SO₄ / tetrahydrofuran; H₂O / 1.5 h

With osmium(VIII) oxide; n-butyllithium; sulfuryl dichloride; 4-methylmorpholine N-oxide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1139/V06-078

Reference yield:

: 872221-71-1
(3aS,4R,5R,6S,7S,7aS)-6,7-dihydroxy-2,2-dimethyl-4-(4-methylphenylsulfonamido)-5-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole

: 872221-73-3
(3aS,4S,5R,6R,7R,7aS)-4-hydroxy-2,2-dimethyl-7-(4-methylphenylsulfonamido)-5-phenylcarbonyloxy-6-(2-trimethylsilyl-1-ethynyl)perhydro-1,3-benzodioxole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 82 percent / triethylamine; SO₂Cl₂ / CH₂Cl₂ / 0 - 20 °C

2.1: dimethylformamide / 2 h / 70 °C

2.2: 33 percent / H₂SO₄ / tetrahydrofuran; H₂O / 1.5 h

With sulfuryl dichloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1139/V06-078