3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

Base Information

Chemical Name:3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester
CAS No.:891090-28-1
Molecular Formula:C₃₉H₆₆N₄O₈
Molecular Weight:718.975
Hs Code.:

Synonyms:3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

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Chemical Property of 3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

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Technology Process of 3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

There total 7 articles about 3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 891090-20-3
N-stearyl-4-(aminomethyl)-3-nitrobenzamide

: 1913-12-8,200334-95-8
β-tert-butyl-N-(tert-butoxycarbonyl)-L-aspartic acid dicyclohexylammonium salt

: 891090-28-1
3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/b503423j DOI:10.1039/b518359f

Reference yield:

: 56-91-7
p-aminomethylbenzoic acid

: 891090-28-1
3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / 2 h / 25 °C

2: 92 percent / aq. nitric acid / 1.5 h / 0 °C

3: K₂CO₃; H₂O / methanol / 10 h / 25 °C

4: 0.67 g / dioxane; H₂O / 2.5 h

5: 81 percent / HOBT; Et₃N; HBTU / CHCl₃ / 10 h / 20 °C

6: 94 percent / HCl / dioxane / 3 h / 20 °C

7: 99 percent / HOBT; HBTU; N-methylmorpholine / dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; water; nitric acid; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1039/b518359f

Reference yield:

: 2372-51-2
4-(aminomethyl)-3-nitrobenzoic acid

: 891090-28-1
3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 0.67 g / dioxane; H₂O / 2.5 h

2: 81 percent / HOBT; Et₃N; HBTU / CHCl₃ / 10 h / 20 °C

3: 94 percent / HCl / dioxane / 3 h / 20 °C

4: 99 percent / HOBT; HBTU; N-methylmorpholine / dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1039/b518359f