3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

Base Information

• Chemical Name: 3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester
• CAS No.: 891090-28-1
• Molecular Formula: C₃₉H₆₆N₄O₈
• Molecular Weight: 718.975
• Mol file: 891090-28-1.mol

Synonyms:3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

Chemical Property of 3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester

There total 7 articles about 3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-stearyl-4-(aminomethyl)-3-nitrobenzamide (891090-20-3) + β-tert-butyl-N-(tert-butoxycarbonyl)-L-aspartic acid dicyclohexylammonium salt (1913-12-8,200334-95-8) → 3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester (891090-28-1)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1039/b503423j DOI:10.1039/b518359f

Reference yield:

p-aminomethylbenzoic acid (56-91-7) → 3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester (891090-28-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 88 percent / 2 h / 25 °C

2: 92 percent / aq. nitric acid / 1.5 h / 0 °C

3: K₂CO₃; H₂O / methanol / 10 h / 25 °C

4: 0.67 g / dioxane; H₂O / 2.5 h

5: 81 percent / HOBT; Et₃N; HBTU / CHCl₃ / 10 h / 20 °C

6: 94 percent / HCl / dioxane / 3 h / 20 °C

7: 99 percent / HOBT; HBTU; N-methylmorpholine / dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; water; nitric acid; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1039/b518359f

Reference yield:

4-(aminomethyl)-3-nitrobenzoic acid (2372-51-2) → 3-t-butoxycarbonylamino-N-(2-nitro-4-octadecylcarbamoylbenzyl)succinamic acid t-butyl ester (891090-28-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 0.67 g / dioxane; H₂O / 2.5 h

2: 81 percent / HOBT; Et₃N; HBTU / CHCl₃ / 10 h / 20 °C

3: 94 percent / HCl / dioxane / 3 h / 20 °C

4: 99 percent / HOBT; HBTU; N-methylmorpholine / dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1039/b518359f

upstream raw materials:

N-stearyl-4-(aminomethyl)-3-nitrobenzamide

β-tert-butyl-N-(tert-butoxycarbonyl)-L-aspartic acid dicyclohexylammonium salt

4-[[(2,2,2-trifluoroacetyl)amino]methyl]benzoic acid

3-nitro-4-{[(trifluoroacetyl)amino]methyl}benzoic acid