(R)-2-[((S)-2-Benzyloxycarbonylamino-propionyl)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-amino]-3-methyl-butyric acid benzyl ester

Base Information

• Chemical Name: (R)-2-[((S)-2-Benzyloxycarbonylamino-propionyl)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-amino]-3-methyl-butyric acid benzyl ester
• CAS No.: 439916-89-9
• Molecular Formula: C₃₁H₃₁N₃O₇
• Molecular Weight: 557.603

Synonyms:(R)-2-[((S)-2-Benzyloxycarbonylamino-propionyl)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-amino]-3-methyl-butyric acid benzyl ester

Chemical Property of (R)-2-[((S)-2-Benzyloxycarbonylamino-propionyl)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-amino]-3-methyl-butyric acid benzyl ester

Chemical Property:

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Technology Process of (R)-2-[((S)-2-Benzyloxycarbonylamino-propionyl)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-amino]-3-methyl-butyric acid benzyl ester

There total 3 articles about (R)-2-[((S)-2-Benzyloxycarbonylamino-propionyl)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-amino]-3-methyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(S)-2-hydroxy-3-methylbutyric acid benzyl ester (65138-05-8) + [(S)-1-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester (287728-93-2) → (R)-2-[((S)-2-Benzyloxycarbonylamino-propionyl)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-amino]-3-methyl-butyric acid benzyl ester (439916-89-9)

Guidance literature:

With dibenzyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

DOI:10.1016/S0040-4039(02)00119-3

Reference yield:

phthalic anhydride (85-44-9) → (R)-2-[((S)-2-Benzyloxycarbonylamino-propionyl)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-amino]-3-methyl-butyric acid benzyl ester (439916-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / DBAD; PPh₃ / tetrahydrofuran / 4 h / 0 - 20 °C

With dibenzyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 2: Mitsunobu reaction;

DOI:10.1016/S0040-4039(02)00119-3

Reference yield:

N-benzyloxycarbonylalaninehydrazid (17350-66-2) → (R)-2-[((S)-2-Benzyloxycarbonylamino-propionyl)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-amino]-3-methyl-butyric acid benzyl ester (439916-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / DBAD; PPh₃ / tetrahydrofuran / 4 h / 0 - 20 °C

With dibenzyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 2: Mitsunobu reaction;

DOI:10.1016/S0040-4039(02)00119-3

upstream raw materials:

(S)-2-hydroxy-3-methylbutyric acid benzyl ester

[(S)-1-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester

phthalic anhydride

N-benzyloxycarbonylalaninehydrazid

Downstream raw materials:

C₃₃H₄₅N₃O₉

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