diethyl α,α-chlorofluoro-4-chlorobenzylphosphonate

Base Information

Chemical Name:diethyl α,α-chlorofluoro-4-chlorobenzylphosphonate
CAS No.:1181811-89-1
Molecular Formula:C₁₁H₁₄Cl₂FO₃P
Molecular Weight:315.109
Hs Code.:

Synonyms:diethyl α,α-chlorofluoro-4-chlorobenzylphosphonate

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Chemical Property of diethyl α,α-chlorofluoro-4-chlorobenzylphosphonate

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Technology Process of diethyl α,α-chlorofluoro-4-chlorobenzylphosphonate

There total 4 articles about diethyl α,α-chlorofluoro-4-chlorobenzylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 57787-10-7
α-chloro-4-chloro-benzyl-phosphonic acid diethyl ester

: 1181811-89-1
diethyl α,α-chlorofluoro-4-chlorobenzylphosphonate

Guidance literature:: α-chloro-4-chloro-benzyl-phosphonic acid diethyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 - -30 ℃; Inert atmosphere;
DOI:10.1055/s-0029-1217564

Reference yield:

: 79177-63-2
diethyl α-fluoro-4-chlorobenzylphosphonate

: 1181811-89-1
diethyl α,α-chlorofluoro-4-chlorobenzylphosphonate

Guidance literature:: diethyl α-fluoro-4-chlorobenzylphosphonate; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

With hexachloroethane; In tetrahydrofuran; at -78 - -30 ℃; Inert atmosphere;
DOI:10.1055/s-0029-1217564

Reference yield:

: 108054-54-2,20641-28-5
diethyl (4-chlorophenyl)(hydroxy)methylphosphonate

: 1181811-89-1
diethyl α,α-chlorofluoro-4-chlorobenzylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

2.2: -78 - -30 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0029-1217564