(R)-2-Amino-N-((S)-1-benzyl-2-oxo-4-phenyl-butyl)-3-(1-formyl-1H-indol-3-yl)-propionamide; hydrochloride

Base Information

Chemical Name:(R)-2-Amino-N-((S)-1-benzyl-2-oxo-4-phenyl-butyl)-3-(1-formyl-1H-indol-3-yl)-propionamide; hydrochloride
CAS No.:126089-41-6
Molecular Formula:C₂₉H₂₉N₃O₃*ClH
Molecular Weight:504.028
Hs Code.:

Synonyms:(R)-2-Amino-N-((S)-1-benzyl-2-oxo-4-phenyl-butyl)-3-(1-formyl-1H-indol-3-yl)-propionamide; hydrochloride

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Chemical Property of (R)-2-Amino-N-((S)-1-benzyl-2-oxo-4-phenyl-butyl)-3-(1-formyl-1H-indol-3-yl)-propionamide; hydrochloride

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Technology Process of (R)-2-Amino-N-((S)-1-benzyl-2-oxo-4-phenyl-butyl)-3-(1-formyl-1H-indol-3-yl)-propionamide; hydrochloride

There total 5 articles about (R)-2-Amino-N-((S)-1-benzyl-2-oxo-4-phenyl-butyl)-3-(1-formyl-1H-indol-3-yl)-propionamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126089-85-8
Boc-D-Trp(CHO)-Phe-CH₂CH₂Ph

: 126089-41-6
(R)-2-Amino-N-((S)-1-benzyl-2-oxo-4-phenyl-butyl)-3-(1-formyl-1H-indol-3-yl)-propionamide; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 1.16667h;
DOI:10.1021/jm00095a013

Reference yield:

: 3277-89-2
phenethylmagnesium bromide

: 126089-41-6
(R)-2-Amino-N-((S)-1-benzyl-2-oxo-4-phenyl-butyl)-3-(1-formyl-1H-indol-3-yl)-propionamide; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 56.8 percent / tetrahydrofuran / 0.5 h / -40 °C

2: anisole, HCl / dioxane; CH₂Cl₂ / 1.25 h / 0 - 20 °C

3: HOBT, 1-ethyl-3-<3-(N,N-dimethylamino)propyl>carbodiimide (WSCD) / dimethylformamide / 3 h / 0 - 20 °C

4: HCl / dioxane; CH₂Cl₂ / 1.17 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00095a013

Reference yield:

: 33900-01-5
Boc-L-phenylalanine 2-pyridyl ester

: 126089-41-6
(R)-2-Amino-N-((S)-1-benzyl-2-oxo-4-phenyl-butyl)-3-(1-formyl-1H-indol-3-yl)-propionamide; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 56.8 percent / tetrahydrofuran / 0.5 h / -40 °C

2: anisole, HCl / dioxane; CH₂Cl₂ / 1.25 h / 0 - 20 °C

3: HOBT, 1-ethyl-3-<3-(N,N-dimethylamino)propyl>carbodiimide (WSCD) / dimethylformamide / 3 h / 0 - 20 °C

4: HCl / dioxane; CH₂Cl₂ / 1.17 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00095a013