4-Methyl-benzenesulfinic acid [(S)-((R)-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phenyl-methyl]-amide

Base Information

Chemical Name:4-Methyl-benzenesulfinic acid [(S)-((R)-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phenyl-methyl]-amide
CAS No.:253308-76-8
Molecular Formula:C₂₃H₂₁NO₄S
Molecular Weight:407.49
Hs Code.:

Synonyms:4-Methyl-benzenesulfinic acid [(S)-((R)-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phenyl-methyl]-amide

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Chemical Property of 4-Methyl-benzenesulfinic acid [(S)-((R)-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phenyl-methyl]-amide

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Technology Process of 4-Methyl-benzenesulfinic acid [(S)-((R)-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phenyl-methyl]-amide

There total 1 articles about 4-Methyl-benzenesulfinic acid [(S)-((R)-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phenyl-methyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4741-62-2
5-methoxyisobenzofuran-1(3H)-one

: 158109-78-5
(R,E)-N-benzylidene-4-methylbenzenesulfinamide

: 4-Methyl-benzenesulfinic acid [(R)-((S)-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phenyl-methyl]-amide

: 253308-76-8
4-Methyl-benzenesulfinic acid [(S)-((R)-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phenyl-methyl]-amide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h; Further Variations:; Solvents; Reagents; various modes of mixing; Product distribution;
DOI:10.1021/jo991119x

Reference yield: 85.0%

: 253308-76-8
4-Methyl-benzenesulfinic acid [(S)-((R)-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phenyl-methyl]-amide

: 253308-77-9
(3S,4R)-(-)-4-hydroxy-6-methoxy-3-phenyl-3,4-dihydro-1(2H)-isoquinolone

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jo991119x

Reference yield:

: 253308-76-8
4-Methyl-benzenesulfinic acid [(S)-((R)-6-methoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phenyl-methyl]-amide

: (3S,4R)-(-)-4-(tert-butyldiphenylsilyloxy)-6-methoxy-N-methyl-3-phenyl-3,4-dihydro-1(2H)-isoquinolone

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / NaH / tetrahydrofuran / 3 h / 20 °C

2: 97 percent / imidazole / CH₂Cl₂ / 1.5 h / 20 °C

3: 97 percent / NaH / tetrahydrofuran / 0.5 h / 20 °C

With 1H-imidazole; sodium hydride; In tetrahydrofuran; dichloromethane; 1: Cyclization / 2: Substitution / 3: Methylation;
DOI:10.1021/jo991119x